Choline

Choline

SCHEMBL3458973

C[N+](C)(C)CCO.C[N+](C)(C)CCO.NC(=O)[O-].[Cl-]

nearest known ligand 0.65

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2

The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.65
SLC5A7 Q9GZV3 1/20 0.65
LMNA P02545 5/20 0.57
MEN1 O00255 1/20 0.57
KMT2A Q03164 1/20 0.57
CHRM5 P08912 4/20 0.46
CHRM1 P11229 4/20 0.46
CHRM3 P20309 4/20 0.46
CHRM2 P08172 3/20 0.46
CHRM4 P08173 3/20 0.46
HTR1A P08908 2/20 0.43
CHRNB2 P17787 2/20 0.43
CYP2C19 P33261 2/20 0.43
CHRNA7 P36544 2/20 0.43
CHRNA4 P43681 2/20 0.43
TSHR P16473 1/20 0.43
GALR3 O60755 1/20 0.39
BLM P54132 2/20 0.38
MAPT P10636 2/20 0.38
POLB P06746 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Choline SCHEMBL7738255 0.97 LMNA (0.60) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL3458979 0.95 LMNA (0.57) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL15993952 0.91 CYP3A4 (0.59) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL516453 0.90 CYP3A4 (0.72) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL28308438 0.90 CYP3A4 (0.72) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL20358854 0.88 LMNA (0.55) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL4211637 0.87 CYP3A4 (0.68) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL16106188 0.87 CYP3A4 (0.68) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL15993921 0.87 CYP3A4 (0.68) CYP3A4SLC5A7LMNAMEN1KMT2A
Choline SCHEMBL28036788 0.87 CYP3A4 (0.68) CYP3A4SLC5A7LMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024214063-A1 METHOD FOR PRESERVATION OF AN ACTIVE COMPOUND, FORMULATION AND PRESERVATIVE IAMFLUIDICS HOLDING B.V. (NL) 2024-10-17 WO claimed
US-4171353-A Immunization of animals using choline esters as an immunological adjuvant RYAN WAYNE L 1979-10-16 US claimed
WO-2024214063-A1 METHOD FOR PRESERVATION OF AN ACTIVE COMPOUND, FORMULATION AND PRESERVATIVE IAMFLUIDICS HOLDING B.V. (NL) 2024-10-17 WO disclosed
US-7803559-B1 Protein aggregation regulators THE REGENTS OF THE UNIVERSITY OF CA (US) 2010-09-28 US disclosed
CN-101375836-A Compound gentamicin-micronomicin injection and preparation method TIANJIN SHENGJI GROUP CO LTD (CN) 2009-03-04 CN disclosed
US-5648070-A Biocompatible anion exchange materials COBE LABORATORIES, INC. (US) 1997-07-15 US disclosed
US-4336400-A BRONCHODILATOR AGENTS, CARDIOVASCULAR STIMULANTS STERLING DRUG INC. (US) 1982-06-22 US disclosed
US-RE30241-E BRONCHODILATION, ADRENERGIC STIMULANTS STERLING DRUG INC. (US) 1980-03-25 US disclosed
US-4171353-A Immunization of animals using choline esters as an immunological adjuvant RYAN WAYNE L 1979-10-16 US disclosed
US-4138581-A BRONCHODILATOR AGENTS, ADRENERGIC STIMULANTS STERLING DRUGS INC. (US) 1979-02-06 US disclosed