SCHEMBL377673

SCHEMBL377673

CC(=O)Oc1ccc(O)c(Br)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.52
LMNA P02545 3/20 0.48
KDM4E B2RXH2 3/20 0.47
MKNK2 Q9HBH9 1/20 0.47
ACHE P22303 2/20 0.46
CA2 P00918 6/20 0.45
POLB P06746 2/20 0.44
MAPT P10636 2/20 0.44
PKM P14618 1/20 0.44
ESR1 P03372 1/20 0.44
CA12 O43570 1/20 0.44
GLA P06280 1/20 0.44
GAA P10253 1/20 0.44
CA9 Q16790 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
ALOX15 P16050 1/20 0.43
MEN1 O00255 1/20 0.43
TTR P02766 1/20 0.43
TP53 P04637 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL50809 0.82 CYP3A4 (0.62) CYP3A4LMNAKDM4EACHECA2
SCHEMBL9477989 0.81 KDM4E (0.56) CYP3A4LMNAKDM4EACHECA2
SCHEMBL11957057 0.81 ACHE (0.59) CYP3A4LMNAKDM4EACHEPOLB
SCHEMBL3932133 0.80 KMT2A (0.50) LMNAKDM4EMKNK2ACHEMAPT
SCHEMBL8576981 0.80 CYP3A4 (0.55) CYP3A4LMNAKDM4EACHEPOLB
SCHEMBL2014098 0.79 LMNA (0.47) CYP3A4LMNAKDM4EACHEPOLB
SCHEMBL12316409 0.79 LMNA (0.47) CYP3A4LMNAKDM4EACHECA2
SCHEMBL2932995 0.79 LMNA (0.47) CYP3A4LMNAKDM4EACHECA2
SCHEMBL286726 0.79 ALDH1A1 (0.58) CYP3A4LMNAKDM4EMAPTGAA
SCHEMBL377390 0.79 SLC22A6 (0.55) CYP3A4LMNAKDM4EMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230210808-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2023-07-06 US disclosed
US-20190192475-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2019-06-27 US disclosed
US-20170304254-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS JANSSEN PHARMACEUTICA NV (DE) 2017-10-26 US disclosed
US-9724322-B2 4-(phenoxyalkyl)thio)-phenoxyacetic acids and analogs JANSSEN PHARMACEUTICA N.V. (BE) 2017-08-08 US disclosed
CN-104011021-B heterocyclic derivatives and their use as prostaglandin D2 receptor modulators 埃科特莱茵药品有限公司 2016-08-24 CN disclosed
US-20160199342-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS CYMABAY THERAPEUTICS, INC. 2016-07-14 US disclosed
US-9193704-B2 Hydantoin derivatives as KV3 inhibitors AUTIFONY THERAPEUTICS LIMITED (GB) 2015-11-24 US disclosed
US-9193704-B2 Hydantoin derivatives as KV3 inhibitors AUTIFONY THERAPEUTICS LIMITED (GB) 2015-11-24 US disclosed
EP-1791812-B1 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS JANSSEN PHARMACEUTICA NV (BE) 2015-11-04 EP disclosed
EP-2243766-B1 4-((phenoxyalkyl)thio)-phenoxyacetic acids for use in treating PPAR-delta mediated conditions JANSSEN PHARMACEUTICA NV (BE) 2015-09-02 EP disclosed
US-20050107469-A1 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs CYMABAY THERAPEUTICS, INC. 2005-05-19 US disclosed
WO-2005042478-A2 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS JANSSEN PHARMACEUTICA, N.V. (BE) 2005-05-12 WO disclosed
WO-2005030694-A1 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS JANSSEN PHARMACEUTICA, N.V. (BE) 2005-04-07 WO disclosed
WO-2005023740-A2 PROCESS FOR THE PREPARATION OF STILBENE DERIVATIVES DSM IP ASSETS B.V. (NL) 2005-03-17 WO disclosed
WO-2004050657-A2 COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE ARTESIAN THERAPEUTICS, INC. (US) 2004-06-17 WO disclosed
WO-2004050657-A2 COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE ARTESIAN THERAPEUTICS, INC. (US) 2004-06-17 WO disclosed
EP-0391212-B1 Process for preparing bifunctional Z-stilbene compounds, new bifunctional Z-stilbene compounds and their use for preparing polymers BAYER AG (DE) 1994-05-25 EP disclosed
US-5136013-A Polyesters BAYER AKTIENGESELLSCHAFT (DE) 1992-08-04 US disclosed
US-5068300-A BIFUNCTIONAL STILBENE COMPOUNDS CONTAINING AT LEAST ONE Z-CONFIGURATED STILBENE GROUP, PROCESS FOR THEIR PREPARATION AND THEIR USE FOR THE PREPARATION OF POLYMERS BAYER AKTIENGESELLSCHAFT (DE) 1991-11-26 US disclosed
EP-0391212-A2 Process for preparing bifunctional Z-stilbene compounds, new bifunctional Z-stilbene compounds and their use for preparing polymers BAYER AG (DE) 1990-10-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190192475-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD CYP3A4 1163/4885LMNA 2274/4885KDM4E 843/4885
US-20230210808-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD CYP3A4 1163/4885LMNA 2274/4885KDM4E 843/4885
US-20170304254-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD CYP3A4 1163/4885LMNA 2274/4885KDM4E 843/4885
US-20050107469-A1 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs PPARA, PPARG, PPARD CYP3A4 1148/4885LMNA 2440/4885KDM4E 1023/4885
US-20160199342-A1 4-(PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS PPARA, PPARG, PPARD CYP3A4 1163/4885LMNA 2274/4885KDM4E 843/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.