Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778882 | 0.88 | NR4A2 (0.71) | NR4A2CYP2C9EGLN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3772163 | 0.87 | NR4A2 (0.69) | NR4A2CYP2C9EGLN1NPC1RAB9A | |
| SCHEMBL3778173 | 0.84 | NR4A2 (0.53) | NR4A2CYP2C9EGLN1DGAT1NPC1 | |
| SCHEMBL3774030 | 0.84 | EGLN1 (0.54) | NR4A2CYP2C9EGLN1DGAT1NPC1 | |
| SCHEMBL3779886 | 0.84 | NR4A2 (0.78) | NR4A2CYP2C9EGLN1NPC1RAB9A | |
| SCHEMBL3776218 | 0.83 | EGLN1 (0.53) | NR4A2CYP2C9EGLN1DGAT1 | |
| SCHEMBL3719799 | 0.83 | NR4A2 (0.53) | NR4A2CYP2C9EGLN1DGAT1NPC1 | |
| SCHEMBL3778604 | 0.82 | NR4A2 (0.50) | NR4A2CYP2C9EGLN1 | |
| SCHEMBL3765085 | 0.82 | EGLN1 (0.50) | NR4A2CYP2C9EGLN1DGAT1NPC1 | |
| SCHEMBL3766957 | 0.82 | NR4A2 (0.57) | NR4A2CYP2C9EGLN1DGAT1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | claimed |
| US-8314109-B2 | 6-heterocyclic-imidazo[1,2-α]pyridine-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2012-11-20 | — | — | US | claimed |
| US-20100317675-A1 | 6-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-12-16 | — | — | US | claimed |
| US-8691990-B2 | 6-heterocyclic imidazo[1,2-α]pyridine-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2014-04-08 | — | — | US | disclosed |
| EP-2225240-B1 | Derivatives of 6-heterocyclic-imidazo[1,2-a]pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2014-01-22 | — | — | EP | disclosed |
| US-20130041152-A1 | 6-HETEROCYCLIC IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | PEYRONEL JEAN-FRANCOIS (FR) | 2013-02-14 | — | — | US | disclosed |
| US-8314109-B2 | 6-heterocyclic-imidazo[1,2-α]pyridine-2-carboxamide derivatives, preparation and therapeutic use thereof | SANOFI (FR) | 2012-11-20 | — | — | US | disclosed |
| US-20100317675-A1 | 6-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130041152-A1 | 6-HETEROCYCLIC IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | XDH, REN, IDH2 | NR4A2 2105/4885CYP2C9 209/4885EGLN1 1986/4885 |
| US-20100317675-A1 | 6-HETEROCYCLIC-IMIDAZO[1,2-a]PYRIDINE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | REN, IDH2, GLS | NR4A2 1987/4885CYP2C9 231/4885EGLN1 1845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.