Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 5/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3780609 | 0.92 | PKM (0.46) | PKMDHFR | |
| SCHEMBL3786585 | 0.88 | PKM (0.43) | PKMDHFR | |
| SCHEMBL1554275 | 0.87 | PKM (0.55) | PKMDHFR | |
| SCHEMBL29352921 | 0.87 | PKM (0.55) | PKMDHFR | |
| SCHEMBL3778205 | 0.86 | PKM (0.43) | PKMDHFR | |
| SCHEMBL16701417 | 0.85 | PKM (0.54) | PKMDHFR | |
| SCHEMBL16701413 | 0.85 | PKM (0.54) | PKMDHFR | |
| SCHEMBL9499492 | 0.85 | PKM (0.54) | PKMDHFR | |
| SCHEMBL30872658 | 0.85 | PKM (0.54) | PKMDHFR | |
| SCHEMBL28201697 | 0.85 | PKM (0.56) | PKMDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | claimed |
| US-8796297-B2 | 4-substituted-2-amino-pyrimidine derivatives | ABBVIE INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331294-A1 | 4-SUBSTITUTED-2-AMINO-PYRIMIDINE DERIVATIVES | HRH2, HRH4, HRH3 | PKM 2598/4885TLR8 743/4885DHFR 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.