Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPMT | P51580 | 5/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA4 | P22748 | 2/20 | 0.51 |
| ▸ | CA6 | P23280 | 2/20 | 0.51 |
| ▸ | CA7 | P43166 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.51 |
| ▸ | CA3 | P07451 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | CA5A | P35218 | 1/20 | 0.51 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3776039 | 0.88 | TPMT (0.64) | TPMTCA12CA1CA2CA4 | |
| SCHEMBL13018858 | 0.86 | KMT2A (0.48) | TPMTCNR2HTTPOLBKMT2A | |
| SCHEMBL28857298 | 0.84 | CA1 (0.69) | TPMTCA12CA1CA2CA4 | |
| 3,4,5-Trimethoxybenzoic Acid SCHEMBL6592 | 0.80 | TPMT (0.78) | TPMTCA12CA1CA2CA4 | |
| SCHEMBL3783450 | 0.80 | TPMT (0.54) | TPMTCA12CA1CA2CA4 | |
| SCHEMBL3787090 | 0.80 | TPMT (0.54) | TPMTCA12CA1CA2CA4 | |
| 3,4,5-Trimethoxybenzoic Acid SCHEMBL10838612 | 0.79 | TPMT (0.75) | TPMTCA12CA1CA2CA4 | |
| 3,4,5-Trimethoxybenzoic Acid SCHEMBL9739818 | 0.79 | TPMT (0.75) | TPMTCA12CA1CA2CA4 | |
| 3,4,5-Trimethoxybenzoic Acid SCHEMBL11023602 | 0.79 | TPMT (0.75) | TPMTCA12CA1CA2CA4 | |
| 3,4,5-Trimethoxybenzoic Acid SCHEMBL4080846 | 0.79 | TPMT (0.75) | TPMTCA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455540-B2 | Gossypol and apogossypol derivatives, preparation thereof and uses thereof | UNIVERSITE DU MAINE (LE MANS) (FR) | 2013-06-04 | — | — | US | disclosed |
| US-8455540-B2 | Gossypol and apogossypol derivatives, preparation thereof and uses thereof | UNIVERSITE DU MAINE (LE MANS) (FR) | 2013-06-04 | — | — | US | disclosed |
| US-8455540-B2 | Gossypol and apogossypol derivatives, preparation thereof and uses thereof | UNIVERSITE DU MAINE (LE MANS) (FR) | 2013-06-04 | — | — | US | disclosed |
| US-20100331398-A1 | DERIVES DU GOSSYPOL ET DE L'APOGOSSYPOL, LEURS PREPARATIONS ET LEURS APPLICTIONS | UNIVERSITE DU MAINE (LE MANS) (FR) | 2010-12-30 | — | — | US | disclosed |
| US-20100331398-A1 | DERIVES DU GOSSYPOL ET DE L'APOGOSSYPOL, LEURS PREPARATIONS ET LEURS APPLICTIONS | UNIVERSITE DU MAINE (LE MANS) (FR) | 2010-12-30 | — | — | US | disclosed |
| WO-2009080949-A1 | GOSSYPOL AND APOGOSSYPOL DERIVATIVES, PREPARATION THEREOF AND USES THEREOF | UNIVERSITE DU MAINE (LE MANS) (FR) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331398-A1 | DERIVES DU GOSSYPOL ET DE L'APOGOSSYPOL, LEURS PREPARATIONS ET LEURS APPLICTIONS | LSS, GRHPR, NR1H3 | TPMT 1528/4885CA12 4201/4885CA1 4847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.