Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12661870 | 0.89 | TSHR (0.72) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL29712918 | 0.89 | TSHR (0.72) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL3773436 | 0.81 | ALDH1A1 (0.46) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL40266 | 0.81 | PKM (0.46) | TSHRALDH1A1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL27820433 | 0.81 | ALDH1A1 (0.46) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL28979865 | 0.81 | ALDH1A1 (0.46) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL1820951 | 0.80 | ALDH1A1 (0.58) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL8440730 | 0.78 | TSHR (0.58) | TSHRALDH1A1TDP1MAPK1 | |
| SCHEMBL28420852 | 0.77 | ALDH1A1 (0.54) | TSHRALDH1A1TDP1GRIN2DGRIN3B | |
| SCHEMBL30073838 | 0.77 | KMT2A (0.42) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2443092-B1 | BICYCLIC AND TRICYCLIC COMPOUNDS AS KAT II INHIBITORS | PFIZER (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8183238-B2 | Bicyclic and tricyclic compounds as KAT II inhibitors | PFIZER INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183238-B2 | Bicyclic and tricyclic compounds as KAT II inhibitors | PFIZER INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183238-B2 | Bicyclic and tricyclic compounds as KAT II inhibitors | PFIZER INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20100324043-A1 | Bicyclic And Tricyclic Compounds As KAT II Inhibitors | PFIZER INC | 2010-12-23 | — | — | US | disclosed |
| US-20100324043-A1 | Bicyclic And Tricyclic Compounds As KAT II Inhibitors | PFIZER INC | 2010-12-23 | — | — | US | disclosed |
| US-20100324043-A1 | Bicyclic And Tricyclic Compounds As KAT II Inhibitors | PFIZER INC | 2010-12-23 | — | — | US | disclosed |
| US-5382693-A | Curing agents for epoxy resins | THE DOW CHEMICAL COMPANY (US) | 1995-01-17 | — | — | US | disclosed |
| WO-1994026690-A1 | BIS(AMINOPHENOXY)-ALPHA-SUBSTITUTED STILBENES, CURABLE MIXTURES WITH EPOXY RESINS AND CURED PRODUCTS | THE DOW CHEMICAL COMPANY (US) | 1994-11-24 | — | — | WO | disclosed |
| US-5300594-A | Bis(aminophenoxy)-alpha-substituted stilbenes, curable mixtures with epoxy resins and cured products | THE DOW CHEMICAL COMPANY (US) | 1994-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324043-A1 | Bicyclic And Tricyclic Compounds As KAT II Inhibitors | KAT2A, KAT2B, KAT6B | TSHR 742/4885ALDH1A1 3989/4885TDP1 738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.