Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1141533 | 0.84 | GSK3B (0.48) | JAK2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1141675 | 0.84 | PRKAA1 (0.58) | JAK2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1141348 | 0.83 | JAK2 (0.46) | JAK2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1141769 | 0.83 | JAK2 (0.46) | JAK2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1141424 | 0.83 | JAK2 (0.48) | JAK2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1141610 | 0.83 | JAK2 (0.51) | JAK2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1141213 | 0.82 | JAK2 (0.47) | JAK2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL27722694 | 0.81 | JAK2 (0.44) | JAK2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL1142174 | 0.81 | JAK2 (0.43) | JAK2GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL12009240 | 0.81 | JAK2 (0.43) | JAK2GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252945-B2 | Protective agent for retinal neuronal cell comprising indazole derivative as active ingredient | UBE INDUSTRIES, LTD. (JP) | 2012-08-28 | — | — | US | disclosed |
| US-8252945-B2 | Protective agent for retinal neuronal cell comprising indazole derivative as active ingredient | UBE INDUSTRIES, LTD. (JP) | 2012-08-28 | — | — | US | disclosed |
| US-8252945-B2 | Protective agent for retinal neuronal cell comprising indazole derivative as active ingredient | UBE INDUSTRIES, LTD. (JP) | 2012-08-28 | — | — | US | disclosed |
| US-8232308-B2 | Methods for treating a disease in which Rho kinase is involved | UBE INDUSTRIES, LTD. (JP) | 2012-07-31 | — | — | US | disclosed |
| EP-2468729-A1 | Novel indazole derivative | UBE INDUSTRIES, LTD. (JP) | 2012-06-27 | — | — | EP | disclosed |
| EP-2468729-A1 | Novel indazole derivative | UBE INDUSTRIES, LTD. (JP) | 2012-06-27 | — | — | EP | disclosed |
| US-20110039891-A1 | Methods for treating a disease in which Rho kinase is involved | UBE INDUSTRIES, LTD. (JP) | 2011-02-17 | — | — | US | disclosed |
| US-7855222-B2 | Methods for treating a disease in which Rho kinase is involved | UBE INDUSTRIES, LTD. (JP) | 2010-12-21 | — | — | US | disclosed |
| US-7855222-B2 | Methods for treating a disease in which Rho kinase is involved | UBE INDUSTRIES, LTD. (JP) | 2010-12-21 | — | — | US | disclosed |
| US-7855222-B2 | Methods for treating a disease in which Rho kinase is involved | UBE INDUSTRIES, LTD. (JP) | 2010-12-21 | — | — | US | disclosed |
| US-7563906-B2 | Indazole derivatives | UBE INDUSTRIES, LTD. (JP) | 2009-07-21 | — | — | US | disclosed |
| US-7563906-B2 | Indazole derivatives | UBE INDUSTRIES, LTD. (JP) | 2009-07-21 | — | — | US | disclosed |
| US-7563906-B2 | Indazole derivatives | UBE INDUSTRIES, LTD. (JP) | 2009-07-21 | — | — | US | disclosed |
| US-20090012123-A1 | Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
| US-20090012123-A1 | Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
| US-20090012123-A1 | Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
| EP-1870099-A1 | PROTECTIVE AGENT FOR RETINAL NEURONAL CELL COMPRISING INDAZOLE DERIVATIVE AS ACTIVE INGREDIENT | Ube Industries, Ltd. (JP) | 2007-12-26 | — | — | EP | disclosed |
| US-20070129404-A1 | Novel indazole derivatives | UBE INDUSTRIES, LTD. (JP) | 2007-06-07 | — | — | US | disclosed |
| US-20070129404-A1 | Novel indazole derivatives | UBE INDUSTRIES, LTD. (JP) | 2007-06-07 | — | — | US | disclosed |
| EP-1679308-A1 | NOVEL INDAZOLE DERIVATIVE | Ube Industries, Ltd. (JP) | 2006-07-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129404-A1 | Novel indazole derivatives | CIT, ROCK1, ROCK2 | JAK2 629/4885GABRA1 1748/4885GABRG2 2750/4885 |
| US-20110039891-A1 | Methods for treating a disease in which Rho kinase is involved | RHOA, ROCK1, ROCK2 | JAK2 317/4885GABRA1 2788/4885GABRG2 3234/4885 |
| US-20090012123-A1 | Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient | GRIK3, ALDH1A2, GRIN3A | JAK2 4880/4885GABRA1 729/4885GABRG2 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.