Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | ALPL | P05186 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.50 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368104 | 0.77 | KDM4E (0.66) | ALDH1A1POLBRAB9AMEN1KMT2A | |
| SCHEMBL11747305 | 0.77 | ALDH1A1 (0.62) | ALDH1A1POLBMEN1KMT2AKDM4E | |
| SCHEMBL3278153 | 0.76 | ALDH1A1 (0.60) | ALDH1A1POLBRAB9AMEN1KMT2A | |
| SCHEMBL4367705 | 0.75 | ALDH1A1 (0.60) | ALDH1A1POLBRAB9AMEN1KMT2A | |
| SCHEMBL20735130 | 0.75 | ALDH1A1 (0.59) | ALDH1A1POLBRAB9AMEN1KMT2A | |
| SCHEMBL17948241 | 0.75 | PRMT1 (0.68) | ALDH1A1POLBMEN1KMT2AKDM4E | |
| SCHEMBL4368102 | 0.73 | CNR2 (0.59) | ALDH1A1POLBRAB9AMEN1KMT2A | |
| SCHEMBL20830396 | 0.71 | ALDH1A1 (0.56) | ALDH1A1POLBRAB9AMEN1KMT2A | |
| SCHEMBL30758585 | 0.71 | ALDH1A1 (0.55) | ALDH1A1POLBRAB9AMEN1KMT2A | |
| SCHEMBL29168848 | 0.71 | ALDH1A1 (0.55) | ALDH1A1POLBRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455540-B2 | Gossypol and apogossypol derivatives, preparation thereof and uses thereof | UNIVERSITE DU MAINE (LE MANS) (FR) | 2013-06-04 | — | — | US | disclosed |
| US-20100331398-A1 | DERIVES DU GOSSYPOL ET DE L'APOGOSSYPOL, LEURS PREPARATIONS ET LEURS APPLICTIONS | UNIVERSITE DU MAINE (LE MANS) (FR) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331398-A1 | DERIVES DU GOSSYPOL ET DE L'APOGOSSYPOL, LEURS PREPARATIONS ET LEURS APPLICTIONS | LSS, GRHPR, NR1H3 | ALDH1A1 2349/4885POLB 4135/4885RAB9A 2628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.