Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 6/20 | 0.55 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.55 |
| ▸ | NQO2 | P16083 | 3/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10100932 | 0.85 | ESR1 (0.55) | HSD17B1HSD17B2CYP2E1CYP3A4CYP2A6 | |
| SCHEMBL7587868 | 0.85 | HSD17B1 (0.62) | HSD17B1HSD17B2NQO2CYP2E1CYP3A4 | |
| SCHEMBL2240182 | 0.85 | HSD17B1 (0.62) | HSD17B1HSD17B2NQO2CYP2E1CYP3A4 | |
| SCHEMBL7591649 | 0.85 | HSD17B1 (0.62) | HSD17B1HSD17B2NQO2CYP2E1CYP3A4 | |
| SCHEMBL2241368 | 0.85 | HSD17B1 (0.62) | HSD17B1HSD17B2NQO2CYP2E1CYP3A4 | |
| SCHEMBL2242666 | 0.85 | HSD17B1 (0.62) | HSD17B1HSD17B2NQO2CYP2E1CYP3A4 | |
| SCHEMBL498650 | 0.83 | HSD17B1 (0.65) | HSD17B1HSD17B2NQO2CYP2E1CYP3A4 | |
| SCHEMBL23263986 | 0.82 | HSD17B1 (0.47) | HSD17B1HSD17B2NQO2CYP2E1CYP3A4 | |
| SCHEMBL26746731 | 0.82 | ESR1 (0.50) | HSD17B1HSD17B2NQO2CYP2E1CYP3A4 | |
| SCHEMBL12562762 | 0.81 | ESR1 (0.52) | HSD17B1HSD17B2CYP3A4CYP2C9ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331550-A1 | THIENOTHIOPHENE DERIVATIVES | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2010-12-30 | — | — | US | claimed |
| US-8329915-B2 | Thienothiophene derivatives | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2012-12-11 | — | — | US | disclosed |
| US-8329915-B2 | Thienothiophene derivatives | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2012-12-11 | — | — | US | disclosed |
| US-20100331550-A1 | THIENOTHIOPHENE DERIVATIVES | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2010-12-30 | — | — | US | disclosed |
| US-20100331550-A1 | THIENOTHIOPHENE DERIVATIVES | NANYANG TECHNOLOGICAL UNIVERSITY (SG) | 2010-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331550-A1 | THIENOTHIOPHENE DERIVATIVES | TST, TPST2, TH | HSD17B1 345/4885HSD17B2 291/4885NQO2 1761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.