SCHEMBL378444

SCHEMBL378444

NCCCCN1CCCC1

nearest known ligand 0.85

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.65
SMN1; SMN2 Q16637 2/20 0.52
KEAP1 Q14145 1/20 0.52
MAPT P10636 1/20 0.50
SIGMAR1 Q99720 2/20 0.48
ALOX15 P16050 1/20 0.48
CYP1A2 P05177 1/20 0.43
MAPK1 P28482 1/20 0.43
ACE2 Q9BYF1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL486410 0.97 HRH3 (0.70) HRH3SMN1; SMN2KEAP1MAPTSIGMAR1
SCHEMBL11179088 0.97 HRH3 (0.70) HRH3SMN1; SMN2KEAP1MAPTSIGMAR1
SCHEMBL6347703 0.97 HRH3 (0.70) HRH3SMN1; SMN2KEAP1MAPTSIGMAR1
Hydrochloric Acid SCHEMBL4710263 0.97 HRH3 (0.62) HRH3SMN1; SMN2KEAP1MAPTSIGMAR1
SCHEMBL854695 0.97 HRH3 (0.70) HRH3SMN1; SMN2KEAP1MAPTSIGMAR1
SCHEMBL8554508 0.97 HRH3 (0.70) HRH3SMN1; SMN2KEAP1MAPTSIGMAR1
SCHEMBL21799578 0.95 HRH3 (0.75) HRH3SMN1; SMN2KEAP1MAPTSIGMAR1
SCHEMBL5839696 0.95 HRH3 (0.75) HRH3SMN1; SMN2KEAP1MAPTSIGMAR1
SCHEMBL21799790 0.95 HRH3 (0.75) HRH3SMN1; SMN2KEAP1MAPTSIGMAR1
SCHEMBL21799504 0.95 HRH3 (0.75) HRH3SMN1; SMN2KEAP1MAPTSIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 397 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120079215-A Composite solvent for removing organic sulfur in industrial synthesis gas and preparation method thereof 远恒(上海)环境科技有限公司 2025-06-03 CN claimed
CN-117915958-A Dendritic structures as non-viral vectors in gene delivery 蒂巴生物技术有限公司 2024-04-19 CN claimed
CN-116272259-B Desulfurization and decarbonization solvent suitable for low-pressure gas and application thereof 四川精事达科技有限公司 2024-02-13 CN claimed
EP-4313170-A1 DENDRITIC ARCHITECTURES AS NONVIRAL VECTORS IN GENE DELIVERY Tiba Biotech LLC (US) 2024-02-07 EP claimed
CN-116272259-A Desulfurization and decarbonization solvent suitable for low-pressure gas and application thereof 四川精事达科技有限公司 2023-06-23 CN claimed
WO-2022212838-A1 DENDRITIC ARCHITECTURES AS NONVIRAL VECTORS IN GENE DELIVERY TIBA BIOTECH LLC (US) 2022-10-06 WO claimed
CN-106914234-B 'Almond-shaped' Mn2O3Preparation method of/C particles 广西大学 2020-11-06 CN claimed
CN-106887606-B Peach-shaped Mn2O3preparation method of/C particles 广西大学 2019-12-13 CN claimed
US-9737875-B2 Affinity reagents for protein purification IMPOSSIBLE FOODS INC. (US) 2017-08-22 US claimed
EP-1926737-B1 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID DERIVATIVES HOFFMANN LA ROCHE (CH) 2017-03-15 EP claimed
US-20070254896-A1 SUBSTITUTED PYRIMIDINE KINASE INHIBITORS JANSSEN PHARMACEUTICA, N.V. (BE) 2007-11-01 US claimed
WO-2007019884-A1 NOVEL 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID AMIDES F. HOFFMANN-LA ROCHE AG (CH) 2007-02-22 WO claimed
US-20060122199-A1 Quinazoline derivatives as src tyrosine kinase inhibitors ASTRAZENECA AB (SE) 2006-06-08 US claimed
US-20050256154-A1 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides LUK KIN-CHUN 2005-11-17 US claimed
EP-1562955-A1 QUINAZOLINE DERIVATIVES AS SRC TYROSINE KINASE INHIBITORS Astrazeneca AB (SE) 2005-08-17 EP claimed
WO-2004041829-A1 QUINAZOLINE DERIVATIVES AS SRC TYROSINE KINASE INHIBITORS ASTRAZENECA AB (SE) 2004-05-21 WO claimed
EP-0614664-B2 Quinolonecarboxylic acid derivatives, their preparation and their use as cell adhesion inhibitors TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-01-08 EP claimed
WO-1999042463-A1 SUBSTITUTED QUINOXALINE DERIVATIVES AS INTERLEUKIN-8 RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1999-08-26 WO claimed
EP-0614664-B1 Quinolonecarboxylic acid derivatives, their preparation and their use as cell adhesion inhibitors TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-09-16 EP claimed
US-5519024-A CELL ADHESION INHIBITOR TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-05-21 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050256154-A1 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides FGFR3, FGFR4, FGFR1 HRH3 938/4885SMN1; SMN2 3141/4885KEAP1 3034/4885
US-20060122199-A1 Quinazoline derivatives as src tyrosine kinase inhibitors SRC, ABL1, ERBB2 HRH3 997/4885SMN1; SMN2 3352/4885KEAP1 1652/4885
US-20070254896-A1 SUBSTITUTED PYRIMIDINE KINASE INHIBITORS DTYMK, TK1, DCK HRH3 2012/4885SMN1; SMN2 2628/4885KEAP1 2255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.