Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 1.00 |
| ▸ | MAPT | P10636 | 11/20 | 1.00 |
| ▸ | NPC1 | O15118 | 11/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | PLEC | Q15149 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734233 | 0.86 | MAPT (0.75) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL31018723 | 0.77 | PLEC (1.00) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9926706 | 0.77 | PLEC (1.00) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL17743028 | 0.74 | PLEC (0.69) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL17730211 | 0.73 | PLEC (0.62) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1718398 | 0.73 | MAPT (0.75) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL25155001 | 0.72 | MAPT (0.69) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4774558 | 0.72 | NPC1 (0.59) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15993268 | 0.72 | PLEC (0.90) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1719059 | 0.72 | MAPT (0.80) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | claimed |
| WO-2010086040-A1 | PYRAZOLO-PYRIMIDINES FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-08-05 | — | — | WO | disclosed |