Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18129364 | 0.86 | CYP3A4 (0.38) | DGAT1CYP3A4TSHRTDP1 | |
| SCHEMBL505464 | 0.73 | CES2 (0.41) | DGAT1KDM1AKDM1BCYP3A4TSHR | |
| SCHEMBL1931981 | 0.73 | KDM1A (0.42) | DGAT1KDM1AKDM1BCYP3A4TSHR | |
| SCHEMBL94537 | 0.73 | CES2 (0.36) | — | |
| SCHEMBL2347204 | 0.71 | CES2 (0.39) | DGAT1KDM1AKDM1BCYP3A4TSHR | |
| SCHEMBL27779904 | 0.71 | CA1 (0.36) | DGAT1KDM1AKDM1B | |
| SCHEMBL18099485 | 0.71 | DGAT1 (0.31) | DGAT1 | |
| SCHEMBL31619139 | 0.69 | CYP3A4 (0.38) | DGAT1KDM1AKDM1BCYP3A4TSHR | |
| SCHEMBL146843 | 0.69 | DGAT1 (0.30) | DGAT1 | |
| SCHEMBL21141913 | 0.69 | ESR1 (0.32) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371298-B2 | Processes for the preparation of isothiazole derivatives | PFIZER INC. (US) | 2016-06-21 | — | — | US | disclosed |
| CN-103764657-B | The pyrrolo-triazine replacing as the methylol aryl of ALK1 inhibitor | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-05-25 | — | — | CN | disclosed |
| WO-2016026830-A1 | NOVEL FUNGICIDAL PYRAZOLE DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2016-02-25 | — | — | WO | disclosed |
| CN-102712619-B | 5-hydroxy pyrimidine-4-carboxamides derivatives | DAIICHI SANKYO Co.,Ltd. (JP) | 2015-11-25 | — | — | CN | disclosed |
| WO-2015160772-A1 | TETRAHYDRO-BENZOIMIDAZOLYL MODULATORS OF TGR5 | JANSSEN PHARMACEUTICA NV (BE) | 2015-10-22 | — | — | WO | disclosed |
| US-20150065726-A1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER INC. | 2015-03-05 | — | — | US | disclosed |
| US-8884025-B2 | Processes for the preparation of isothiazole derivatives | PFIZER INC. | 2014-11-11 | — | — | US | disclosed |
| CN-102712619-A | 5-hydroxypyrimidine-4-carboxamide derivative | DAIICHI SANKYO CO LTD | 2012-10-03 | — | — | CN | disclosed |
| EP-1784183-B1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER (US) | 2012-01-25 | — | — | EP | disclosed |
| CN-102203093-A | Aminotriazolopyridines and their use as kinase inhibitors | SIGNAL PHARM LLC | 2011-09-28 | — | — | CN | disclosed |
| US-20090023924-A1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER INC. | 2009-01-22 | — | — | US | disclosed |
| EP-1784183-A2 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | Pfizer Products Incorporated (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006026034-A2 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023924-A1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | CYP3A4, CYP3A43, CYP2F1 | DGAT1 3669/4885KDM1A 2652/4885KDM1B 3396/4885 |
| US-20150065726-A1 | PROCESSES FOR THE PREPARATION OF ISOTHIAZOLE DERIVATIVES | CYP3A4, CYP3A43, CYP2F1 | DGAT1 3758/4885KDM1A 3294/4885KDM1B 3843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.