Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | APAF1 | O14727 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | P4HB | P07237 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.46 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6723448 | 0.81 | POLB (0.53) | SMN1; SMN2MAPTPOLBKDM4EAPAF1 | |
| SCHEMBL20510013 | 0.81 | P4HB (0.57) | SMN1; SMN2MAPTPOLBKDM4EAPAF1 | |
| SCHEMBL20510012 | 0.81 | P4HB (0.57) | SMN1; SMN2MAPTPOLBKDM4EAPAF1 | |
| SCHEMBL3783713 | 0.79 | KDM4E (0.57) | MAPTKDM4EMEN1LMNAMPO | |
| SCHEMBL3784345 | 0.79 | KDM4E (0.57) | MAPTKDM4EMEN1LMNAMPO | |
| SCHEMBL3783712 | 0.79 | KDM4E (0.57) | MAPTKDM4EMEN1LMNAMPO | |
| SCHEMBL7417802 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTPOLBKDM4EAPAF1 | |
| SCHEMBL7417808 | 0.79 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPTPOLBKDM4EAPAF1 | |
| SCHEMBL23100718 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTPOLBKDM4EAPAF1 | |
| SCHEMBL23100716 | 0.79 | SMN1; SMN2 (0.59) | SMN1; SMN2MAPTPOLBKDM4EAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260022-B1 | SUBSTITUTED CYCLOHEXYLDIAMINES | GRUENENTHAL GMBH (DE) | 2017-01-04 | — | — | EP | disclosed |
| US-8357705-B2 | Substituted cyclohexyldiamines | GRUENENTHAL GMBH (DE) | 2013-01-22 | — | — | US | disclosed |
| EP-2260022-A1 | SUBSTITUTED CYCLOHEXYLDIAMINES | Grünenthal GmbH (DE) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009118174-A1 | SUBSTITUTED CYCLOHEXYLDIAMINES | Grünenthal GmbH (DE) | 2009-10-01 | — | — | WO | disclosed |
| US-20090247591-A1 | SUBSTITUTED CYCLOHEXYLDIAMINES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247591-A1 | SUBSTITUTED CYCLOHEXYLDIAMINES | OPRL1, OPRD1, OPRK1 | SMN1; SMN2 1227/4885MAPT 1952/4885POLB 3649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.