Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3765565 | 0.94 | P2RX7 (0.48) | P2RX7MEN1KMT2APOLBHDAC6 | |
| SCHEMBL3759804 | 0.85 | HDAC6 (0.48) | P2RX7POLBHDAC6SMN1; SMN2HTT | |
| SCHEMBL3791796 | 0.85 | HTT (0.53) | MEN1KMT2ASMN1; SMN2KDM4EHTT | |
| SCHEMBL3755499 | 0.84 | P2RX7 (0.41) | P2RX7KMT2APOLBHDAC6SMN1; SMN2 | |
| SCHEMBL3759965 | 0.83 | P2RX7 (0.45) | P2RX7KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL3761284 | 0.82 | HTT (0.58) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL3759959 | 0.82 | P2RX7 (0.41) | P2RX7KMT2ASMN1; SMN2LMNA | |
| SCHEMBL3785778 | 0.82 | KMT2A (0.53) | P2RX7KMT2AHTTALDH1A1LMNA | |
| SCHEMBL3762001 | 0.81 | KMT2A (0.50) | P2RX7MEN1KMT2AHDAC6SMN1; SMN2 | |
| SCHEMBL3760532 | 0.79 | ALDH1A1 (0.57) | P2RX7MEN1KMT2AHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138828-A2 | POTASSIUM CHANNEL MODULATORS | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |