Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.68 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.68 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.48 |
| ▸ | TAOK3 | Q9H2K8 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7909264 | 0.90 | ATM (0.52) | MTNR1AMTNR1BCA1CA2ACHE | |
| Carbamic Acid SCHEMBL7763164 | 0.84 | ATM (0.48) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL9490334 | 0.83 | CA1 (0.73) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL3682479 | 0.81 | MTNR1A (0.66) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL29565539 | 0.81 | MTNR1A (0.66) | MTNR1AMTNR1BCA1CA2ACHE | |
| SCHEMBL2597383 | 0.81 | MTNR1A (1.00) | MTNR1AMTNR1BDRD2MAOAMAOB | |
| SCHEMBL827706 | 0.81 | MTNR1A (1.00) | MTNR1AMTNR1BDRD2MAOAMAOB | |
| SCHEMBL4112887 | 0.81 | MTNR1A (1.00) | MTNR1AMTNR1BDRD2MAOAMAOB | |
| SCHEMBL9725906 | 0.81 | MTNR1A (0.57) | MTNR1AMTNR1BMAOAMAOBCYP1A2 | |
| SCHEMBL30612411 | 0.80 | MTNR1A (0.73) | MTNR1AMTNR1BCA1CA2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396296-A1 | AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | Abbott GmbH & Co. KG (DE) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092180-A1 | Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT GMBH & CO. KG (DE) | 2010-08-19 | — | — | WO | disclosed |