Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GRM7 | Q14831 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL7763164 | 0.94 | ATM (0.48) | ATMMTNR1AMTNR1BHRH3DRD2 | |
| SCHEMBL3786131 | 0.90 | MTNR1A (0.68) | ATMMTNR1AMTNR1BDRD2MAPT | |
| SCHEMBL10616615 | 0.86 | ATM (0.45) | ATMMTNR1AMTNR1BDRD2NFKB1 | |
| SCHEMBL8565940 | 0.83 | EPHX2 (0.70) | ATMMTNR1AMTNR1BDRD2MAPT | |
| SCHEMBL8565942 | 0.83 | EPHX2 (0.70) | ATMMTNR1AMTNR1BDRD2MAPT | |
| SCHEMBL6502466 | 0.82 | MEN1 (0.55) | MTNR1AMTNR1BHRH3MAPTGRM7 | |
| SCHEMBL170233 | 0.81 | ALDH1A1 (0.65) | MEN1KMT2ACA1CA2ACHE | |
| SCHEMBL10615382 | 0.79 | KDM4E (0.53) | ATMDRD2NFKB1NFKB2RELA | |
| SCHEMBL10616751 | 0.78 | HPGD (0.44) | ATMDRD2MAPTCA1CA2 | |
| SCHEMBL173219 | 0.78 | EPHX2 (0.69) | MTNR1AMTNR1BDRD2MAPTGRM7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197798-B1 | INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN | NOVARTIS AG (CH) | 2001-03-06 | — | — | US | disclosed |
| US-5272157-A | Derivatives of 4-(aminomethyl) piperidine, their preparation and their therapeutic application | SYNTHELABO (FR) | 1993-12-21 | — | — | US | disclosed |
| US-5179108-A | Antiserotonin agents or cardiovascular disorders | SYNTHELABO (FR) | 1993-01-12 | — | — | US | disclosed |