Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13018240 | 0.88 | LMNA (0.44) | MAPTRAB9ALMNATP53HTT | |
| SCHEMBL3781334 | 0.88 | LMNA (0.44) | MAPTRAB9ALMNATP53HTT | |
| SCHEMBL474013 | 0.80 | PDE2A (0.51) | HTR2ASLC6A4KCNH2HPGDKDM4E | |
| SCHEMBL2196932 | 0.76 | HTR2A (0.40) | MAPTRAB9ALMNAHTR2ASLC6A4 | |
| SCHEMBL8342327 | 0.76 | HTR2A (0.50) | LMNATP53HTTHTR2ASLC6A4 | |
| SCHEMBL3788314 | 0.75 | TP53 (0.44) | MAPTRAB9ALMNATP53HTT | |
| SCHEMBL7784230 | 0.75 | ADRA1A (0.45) | LMNAHTR2ASLC6A4KCNH2MEN1 | |
| SCHEMBL5462394 | 0.75 | AKR1C3 (0.44) | HTR2ASLC6A4KCNH2KDM4ETDP1 | |
| SCHEMBL6203042 | 0.74 | TP53 (0.52) | MAPTRAB9ALMNATP53HTT | |
| SCHEMBL2817075 | 0.74 | HTR2A (0.49) | LMNATP53HTTHTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858825-B2 | Acid and base stable diphenylmethanol derivatives and methods of use | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-12-28 | — | — | US | disclosed |
| US-20080200719-A1 | Acid and base stable diphenylmethanol derivatives and methods of use | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200719-A1 | Acid and base stable diphenylmethanol derivatives and methods of use | DPYD, DHODH, DAO | MAPT 1367/4885RAB9A 2848/4885LMNA 693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.