SCHEMBL3787230

SCHEMBL3787230

COC(=O)Nc1cc(Cl)cc(NC(=O)OC)c1

nearest known ligand 0.58

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.53
MAPT P10636 5/20 0.50
MEN1 O00255 4/20 0.50
KMT2A Q03164 4/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
HPGD P15428 3/20 0.50
ALDH1A1 P00352 2/20 0.50
XBP1 P17861 1/20 0.50
HTT P42858 1/20 0.50
ALOX15 P16050 1/20 0.46
RAB9A P51151 3/20 0.46
NPSR1 Q6W5P4 2/20 0.46
SLC13A3 Q8WWT9 1/20 0.44
P2RY1 P47900 1/20 0.43
NPC1 O15118 1/20 0.43
POLB P06746 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2095417 0.96 L3MBTL1 (0.58) L3MBTL1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL11656945 0.89 SMN1; SMN2 (0.60) MAPTMEN1KMT2ASMN1; SMN2HPGD
SCHEMBL9630497 0.87 GRM4 (0.49) L3MBTL1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL3786311 0.80 KDM4E (0.60) L3MBTL1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL1188370 0.80 HPGD (0.71) MAPTMEN1KMT2ASMN1; SMN2HPGD
SCHEMBL3786493 0.80 L3MBTL1 (0.44) L3MBTL1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL31153302 0.79 MAPT (0.53) MAPTMEN1KMT2ASMN1; SMN2HPGD
SCHEMBL6200925 0.79 MEN1 (0.51) L3MBTL1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL3786021 0.79 SMN1; SMN2 (0.64) L3MBTL1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL1188088 0.78 SMN1; SMN2 (0.67) L3MBTL1MAPTMEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2010-04-08 US disclosed
EP-1914221-A1 PROCESS FOR PRODUCING BIARYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2008-04-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND NISCH, BLVRB, BBOX1 L3MBTL1 3838/4885MAPT 3312/4885MEN1 174/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.