Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CD44 | P16070 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8999976 | 0.83 | CYP3A4 (0.48) | ALDH1A1TSHRNR4A2CYP3A4PIK3CA | |
| SCHEMBL16746561 | 0.83 | CYP1A2 (0.43) | ALDH1A1TSHRCYP3A4KMT2AGAA | |
| SCHEMBL26529872 | 0.78 | ALDH1A1 (0.44) | ALDH1A1TSHRNR4A2CYP3A4PIK3CA | |
| SCHEMBL26119736 | 0.77 | ALDH1A1 (0.42) | ALDH1A1TSHRNR4A2CYP3A4PIK3CA | |
| SCHEMBL21395985 | 0.74 | ESR1 (0.40) | ALDH1A1TSHRGAAKDM4ELMNA | |
| SCHEMBL3787606 | 0.74 | MAPT (0.44) | ALDH1A1TSHRNR4A2KMT2AGAA | |
| SCHEMBL18509851 | 0.74 | CD44 (0.52) | ALDH1A1TSHRCYP3A4PIK3CAKDM4E | |
| SCHEMBL171322 | 0.73 | — | — | |
| SCHEMBL14382392 | 0.73 | AOC3 (0.42) | ALDH1A1TSHRNR4A2CYP3A4LMNA | |
| SCHEMBL29512603 | 0.73 | TSHR (0.43) | ALDH1A1TSHRNR4A2KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220251079-A1 | BENZO[B][1,8]NAPHTHYRIDINE ACETIC ACID DERIVATIVES AND METHODS OF USE | Stingthera, Inc. | 2022-08-11 | — | — | US | disclosed |
| CN-114391015-A | Benzo [ b ] [1,8] naphthyridineacetic acid derivatives and methods of use | 斯汀塞拉股份有限公司 | 2022-04-22 | — | — | CN | disclosed |
| EP-3969452-A1 | BENZO[B][1,8]NAPHTHYRIDINE ACETIC ACID DERIVATIVES AND METHODS OF USE | Stingthera, Inc. (US) | 2022-03-23 | — | — | EP | disclosed |
| US-20210002230-A1 | OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE | Stingthera, Inc. | 2021-01-07 | — | — | US | disclosed |
| WO-2020232378-A1 | BENZO[B][1,8]NAPHTHYRIDINE ACETIC ACID DERIVATIVES AND METHODS OF USE | SILICON SWAT, INC. (US) | 2020-11-19 | — | — | WO | disclosed |
| WO-2020232378-A1 | BENZO[B][1,8]NAPHTHYRIDINE ACETIC ACID DERIVATIVES AND METHODS OF USE | SILICON SWAT, INC. (US) | 2020-11-19 | — | — | WO | disclosed |
| WO-2020232375-A1 | OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE | SILICON SWAT, INC. (US) | 2020-11-19 | — | — | WO | disclosed |
| US-10745358-B2 | Oxoacridinyl acetic acid derivatives and methods of use | SILICON SWAT, INC. (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190161449-A1 | OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE | SILICON SWAT, INC. | 2019-05-30 | — | — | US | disclosed |
| US-20100087680-A1 | METHOD FOR PRODUCING BIARYL COMPOUND | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2010-04-08 | — | — | US | disclosed |
| EP-1914221-A1 | PROCESS FOR PRODUCING BIARYL COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190161449-A1 | OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE | STING1, IRF3, CGAS | ALDH1A1 1078/4885TSHR 4454/4885NR4A2 2420/4885 |
| US-20100087680-A1 | METHOD FOR PRODUCING BIARYL COMPOUND | NISCH, BLVRB, BBOX1 | ALDH1A1 4339/4885TSHR 1688/4885NR4A2 888/4885 |
| US-20220251079-A1 | BENZO[B][1,8]NAPHTHYRIDINE ACETIC ACID DERIVATIVES AND METHODS OF USE | STING1, IRF3, CGAS | ALDH1A1 985/4885TSHR 4225/4885NR4A2 681/4885 |
| US-20210002230-A1 | OXOACRIDINYL ACETIC ACID DERIVATIVES AND METHODS OF USE | STING1, IRF3, CGAS | ALDH1A1 1078/4885TSHR 4454/4885NR4A2 2420/4885 |
| US-10745358-B2 | Oxoacridinyl acetic acid derivatives and methods of use | STING1, IRF3, CGAS | ALDH1A1 1078/4885TSHR 4454/4885NR4A2 2420/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.