Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.53 |
| ▸ | KLF5 | Q13887 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.49 |
| ▸ | WNT3A | P56704 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787714 | 0.81 | HPGD (0.54) | MAPTNPC1RAB9APAX8KLF5 | |
| SCHEMBL1569557 | 0.75 | PTGDR2 (0.69) | PTGDR2 | |
| SCHEMBL15979797 | 0.74 | CTNNB1 (0.84) | CTNNB1WNT3A | |
| SCHEMBL29111414 | 0.74 | MTNR1A (0.65) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL26115654 | 0.73 | KDM4E (0.68) | MAPTNPC1RAB9APAX8KLF5 | |
| SCHEMBL8882813 | 0.73 | MEN1 (0.52) | TAAR1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL3787786 | 0.72 | TAS1R3 (0.61) | NPC1RAB9AROCK2ROCK1CTNNB1 | |
| SCHEMBL8317337 | 0.72 | CTNNB1 (0.56) | KMT2ANPC1RAB9APAX8KLF5 | |
| SCHEMBL28860886 | 0.72 | CTNNB1 (0.60) | KMT2ANPC1RAB9ACTNNB1WNT3A | |
| SCHEMBL671055 | 0.72 | CTNNB1 (0.57) | NPC1RAB9ATDP1CTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234486-A1 | BENZIMIDAZOLES AND ANALOGS AS RHO KINASE INHIBITORS | The Scripps Research Institute (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079011-A1 | BENZIMIDAZOLES AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-06-25 | — | — | WO | disclosed |