SCHEMBL378828

SCHEMBL378828

Brc1cc(Br)cc(-c2ccc(OCc3ccccc3)cc2)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSTP1 P09211 2/20 0.58
MAOB P27338 5/20 0.57
MCL1 Q07820 3/20 0.56
LMNA P02545 1/20 0.55
CYP1A2 P05177 1/20 0.55
PTGS1 P23219 1/20 0.55
SLC6A2 P23975 1/20 0.55
CYP2C19 P33261 1/20 0.55
PTGS2 P35354 1/20 0.55
SLC6A3 Q01959 1/20 0.55
HIF1A Q16665 1/20 0.55
HDAC6 Q9UBN7 1/20 0.55
GAA P10253 1/20 0.53
MAPT P10636 1/20 0.53
MAOA P21397 1/20 0.53
RAB9A P51151 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
ALOX5 P09917 1/20 0.51
BCHE P06276 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8616107 0.87 MCL1 (0.60) GSTP1MAOBMCL1LMNACYP1A2
SCHEMBL7665986 0.87 MCL1 (0.60) GSTP1MAOBMCL1LMNACYP1A2
SCHEMBL4196989 0.87 MAOB (0.68) GSTP1MAOBMCL1LMNACYP1A2
SCHEMBL197017 0.85 LMNA (0.72) GSTP1MAOBMCL1LMNACYP1A2
SCHEMBL308991 0.83 MAOB (0.72) GSTP1MAOBLMNACYP1A2PTGS1
SCHEMBL23483029 0.83 LMNA (0.69) GSTP1MAOBMCL1LMNACYP1A2
SCHEMBL1096817 0.83 LMNA (0.69) GSTP1MAOBMCL1LMNACYP1A2
SCHEMBL8641406 0.82 MAOB (0.57) GSTP1MAOBMCL1LMNACYP1A2
SCHEMBL23641068 0.82 PTPN1 (0.59) GSTP1MAOBMCL1LMNACYP1A2
SCHEMBL8162120 0.81 MAOB (0.67) GSTP1MAOBMAOAFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8313669-B2 Liquid-crystal display MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 2012-11-20 US disclosed
US-8313669-B2 Liquid-crystal display MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 2012-11-20 US disclosed
US-8313669-B2 Liquid-crystal display MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 2012-11-20 US disclosed
EP-2181174-B1 LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2012-01-25 EP disclosed
EP-2181174-B1 LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2012-01-25 EP disclosed
US-20110101269-A1 LIQUID-CRYSTAL DISPLAY MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2011-05-05 US disclosed
US-20110101269-A1 LIQUID-CRYSTAL DISPLAY MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2011-05-05 US disclosed
US-20110101269-A1 LIQUID-CRYSTAL DISPLAY MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2011-05-05 US disclosed
EP-2181174-A1 LIQUID CRYSTAL DISPLAY Merck Patent GmbH (DE) 2010-05-05 EP disclosed
WO-2009030322-A1 LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2009-03-12 WO disclosed
WO-2009030322-A1 LIQUID CRYSTAL DISPLAY MERCK PATENT GMBH (DE) 2009-03-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110101269-A1 LIQUID-CRYSTAL DISPLAY KLK3, LPXN, PSAP GSTP1 4165/4885MAOB 3582/4885MCL1 793/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.