Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3798917 | 0.90 | EPHX2 (0.39) | EPHX2DDR1RIPK1ROCK2ROCK1 | |
| SCHEMBL13257875 | 0.90 | EPHX2 (0.38) | EPHX2DDR1RIPK1ROCK2ROCK1 | |
| SCHEMBL3790712 | 0.90 | EPHX2 (0.51) | EPHX2DDR1RIPK1ROCK2ROCK1 | |
| SCHEMBL3790162 | 0.86 | EPHX2 (0.51) | EPHX2DDR1RIPK1ROCK2ROCK1 | |
| SCHEMBL3788876 | 0.85 | RIPK1 (0.38) | EPHX2DDR1RIPK1ROCK2ROCK1 | |
| SCHEMBL3710884 | 0.85 | EPHX2 (0.47) | EPHX2DDR1ROCK2LMNA | |
| SCHEMBL3788739 | 0.85 | DDR1 (0.37) | DDR1 | |
| SCHEMBL3788832 | 0.83 | EPHX2 (0.40) | EPHX2DDR1RIPK1ROCK2ROCK1 | |
| SCHEMBL3788935 | 0.79 | EPHX2 (0.47) | EPHX2RIPK1ROCK2ROCK1 | |
| SCHEMBL3805799 | 0.79 | DDR1 (0.41) | EPHX2DDR1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |