Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | OTC | P00480 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL16553031 | 0.99 | ITGB3 (0.47) | ITGB3ITGA2BCYP2D6MAPK1SLC1A3 | |
| Arginine SCHEMBL956656 | 0.99 | ITGB3 (0.47) | ITGB3ITGA2BCYP2D6MAPK1SLC1A3 | |
| Arginine SCHEMBL16552839 | 0.88 | CASR (0.44) | CYP2D6MAPK1CASRKIF11TSHR | |
| Arginine SCHEMBL16553173 | 0.88 | CASR (0.44) | CYP2D6MAPK1CASRKIF11TSHR | |
| Arginine SCHEMBL16879777 | 0.84 | KIF11 (0.47) | KIF11TDP1OTC | |
| SCHEMBL10947926 | 0.83 | CYP2D6 (0.43) | ITGB3ITGA2BCYP2D6MAPK1SLC1A3 | |
| SCHEMBL10947915 | 0.83 | CYP2D6 (0.43) | ITGB3ITGA2BCYP2D6MAPK1SLC1A3 | |
| Arginine SCHEMBL17874428 | 0.82 | PMP22 (0.50) | TSHROTC | |
| Arginine SCHEMBL6468370 | 0.82 | PMP22 (0.50) | TSHROTC | |
| Arginine SCHEMBL6468371 | 0.82 | PMP22 (0.50) | TSHROTC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222754-A2 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | Cornell University (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009073541-A2 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | CORNELL UNIVERSITY (US) | 2009-06-11 | — | — | WO | disclosed |