Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | OTC | P00480 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL16553031 | 1.00 | ITGB3 (0.47) | ITGB3ITGA2BCYP2D6MAPK1SLC1A3 | |
| Arginine SCHEMBL3789787 | 0.99 | ITGB3 (0.46) | ITGB3ITGA2BCYP2D6MAPK1SLC1A3 | |
| Arginine SCHEMBL16552839 | 0.89 | CASR (0.44) | CYP2D6MAPK1CASRKIF11TSHR | |
| Arginine SCHEMBL16553173 | 0.89 | CASR (0.44) | CYP2D6MAPK1CASRKIF11TSHR | |
| Arginine SCHEMBL16879777 | 0.85 | KIF11 (0.47) | KIF11TDP1OTC | |
| SCHEMBL10947915 | 0.84 | CYP2D6 (0.43) | ITGB3ITGA2BCYP2D6MAPK1SLC1A3 | |
| SCHEMBL10947926 | 0.84 | CYP2D6 (0.43) | ITGB3ITGA2BCYP2D6MAPK1SLC1A3 | |
| Arginine SCHEMBL6468370 | 0.83 | PMP22 (0.50) | TSHROTC | |
| Arginine SCHEMBL17874428 | 0.83 | PMP22 (0.50) | TSHROTC | |
| Arginine SCHEMBL6468371 | 0.83 | PMP22 (0.50) | TSHROTC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110008441-A1 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-01-13 | — | — | US | claimed |
| EP-2222754-A2 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | Cornell University (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2009073541-A2 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | CORNELL UNIVERSITY (US) | 2009-06-11 | — | — | WO | claimed |
| US-20240181063-A1 | Liquid Protein Formulations Containing Viscosity-Lowering Agents | EAGLE BIOLOGICS, INC. | 2024-06-06 | — | — | US | disclosed |
| EP-3791862-B1 | LIQUID PROTEIN FORMULATIONS CONTAINING VISCOSITY-LOWERING AGENTS | EAGLE BIOLOGICS INC (US) | 2024-05-29 | — | — | EP | disclosed |
| US-20210085792-A1 | Liquid Protein Formulations Containing Viscosity-Lowering Agents | EAGLE BIOLOGICS, INC. | 2021-03-25 | — | — | US | disclosed |
| EP-3791862-A1 | LIQUID PROTEIN FORMULATIONS CONTAINING VISCOSITY-LOWERING AGENTS | Eagle Biologics, Inc. (US) | 2021-03-17 | — | — | EP | disclosed |
| US-10849977-B2 | Liquid Protein Formulations Containing Thiamine | EAGLE BIOLOGICS, INC. (US) | 2020-12-01 | — | — | US | disclosed |
| EP-3043775-B1 | LIQUID PROTEIN FORMULATIONS CONTAINING VISCOSITY-LOWERING AGENTS | EAGLE BIOLOGICS INC (US) | 2020-11-04 | — | — | EP | disclosed |
| US-10646571-B2 | Liquid protein formulations containing cimetidine | EAGLE BIOLOGICS, INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-20180177875-A1 | Liquid Protein Formulations Containing Cimetidine | EAGLE BIOLOGICS, INC. | 2018-06-28 | — | — | US | disclosed |
| US-9925263-B2 | Liquid pharmaceutical formulations for injection comprising procaine and uses thereof | EAGLE BIOLOGICS, INC. (US) | 2018-03-27 | — | — | US | disclosed |
| EP-2222754-B1 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | UNIV CORNELL (US) | 2018-01-10 | — | — | EP | disclosed |
| EP-3043775-A2 | LIQUID PROTEIN FORMULATIONS CONTAINING VISCOSITY-LOWERING AGENTS | Arsia Therapeutics, Inc. (US) | 2016-07-20 | — | — | EP | disclosed |
| WO-2015038818-A2 | LIQUID PROTEIN FORMULATIONS CONTAINING VISCOSITY-LOWERING AGENTS | Arsia Therapeutics, Inc. (US) | 2015-03-19 | — | — | WO | disclosed |
| US-20150071925-A1 | LIQUID PROTEIN FORMULATIONS CONTAINING VISCOSITY-LOWERING AGENTS | EAGLE BIOLOGICS, INC. | 2015-03-12 | — | — | US | disclosed |
| US-8858998-B2 | Thermoresponsive arginine-based hydrogels as biologic carriers | CORNELL UNIVERSITY (US) | 2014-10-14 | — | — | US | disclosed |
| US-20110008441-A1 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-01-13 | — | — | US | disclosed |
| EP-2222754-A2 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | Cornell University (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009073541-A2 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | CORNELL UNIVERSITY (US) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10849977-B2 | Liquid Protein Formulations Containing Thiamine | SLC19A2, TTPA, SLC7A5 | ITGB3 653/4885ITGA2B 519/4885CYP2D6 3139/4885 |
| US-20210085792-A1 | Liquid Protein Formulations Containing Viscosity-Lowering Agents | ALB, PDE8A, IGFBP1 | ITGB3 1388/4885ITGA2B 941/4885CYP2D6 4165/4885 |
| US-20150071925-A1 | LIQUID PROTEIN FORMULATIONS CONTAINING VISCOSITY-LOWERING AGENTS | ALB, PDE8A, IGFBP1 | ITGB3 1388/4885ITGA2B 941/4885CYP2D6 4165/4885 |
| US-20180177875-A1 | Liquid Protein Formulations Containing Cimetidine | ALB, FABP2, MAX | ITGB3 1358/4885ITGA2B 712/4885CYP2D6 1266/4885 |
| US-20110008441-A1 | THERMORESPONSIVE ARGININE-BASED HYDROGELS AS BIOLOGIC CARRIERS | PARG, PNISR, PUF60 | ITGB3 4583/4885ITGA2B 4221/4885CYP2D6 3631/4885 |
| US-10646571-B2 | Liquid protein formulations containing cimetidine | ALB, FABP2, MAX | ITGB3 1358/4885ITGA2B 712/4885CYP2D6 1266/4885 |
| US-20240181063-A1 | Liquid Protein Formulations Containing Viscosity-Lowering Agents | ALB, PDE8A, IGFBP1 | ITGB3 1388/4885ITGA2B 941/4885CYP2D6 4165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.