Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 1.00 |
| ▸ | DRD2 | P14416 | 3/20 | 1.00 |
| ▸ | DRD3 | P35462 | 2/20 | 1.00 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 1.00 |
| ▸ | HTR3B | O95264 | 2/20 | 1.00 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 1.00 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 1.00 |
| ▸ | ADRB1 | P08588 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | HTR6 | P50406 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 0.96 |
| ▸ | MAPT | P10636 | 1/20 | 0.96 |
| ▸ | HTR7 | P34969 | 3/20 | 0.76 |
| ▸ | HTR1A | P08908 | 5/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.65 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29396943 | 1.00 | HTR3A (1.00) | HTR3ADRD2DRD3HTR3EHTR3B | |
| SCHEMBL6366499 | 1.00 | HTR3A (1.00) | HTR3ADRD2DRD3HTR3EHTR3B | |
| Bromide SCHEMBL27797305 | 0.98 | HTR3A (0.96) | HTR3ADRD2DRD3HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL246416 | 0.98 | LMNA (1.00) | HTR3ADRD2DRD3HTR3EHTR3B | |
| Piperazine SCHEMBL28843777 | 0.98 | HTR3A (0.96) | HTR3ADRD2DRD3HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL29397565 | 0.98 | LMNA (1.00) | HTR3ADRD2DRD3HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL6602545 | 0.98 | LMNA (1.00) | HTR3ADRD2DRD3HTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL9069817 | 0.96 | HTR3A (0.93) | HTR3ADRD2DRD3HTR3EHTR3B | |
| Iodide SCHEMBL27505006 | 0.96 | HTR3A (0.93) | HTR3ADRD2DRD3HTR3EHTR3B | |
| Alcohol SCHEMBL7289118 | 0.93 | DRD2 (0.87) | HTR3ADRD2DRD3HTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2954 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118125995-A | Synthesis method of 1- (2-methoxyphenyl) piperazine hydrochloride | 南昌大学抚州医学院 | 2024-06-04 | — | — | CN | claimed |
| CN-115108999-B | Phenyl piperazine quinazoline compound or pharmaceutically acceptable salt thereof, preparation method and application | 暨南大学 | 2023-11-03 | — | — | CN | claimed |
| CN-114163402-B | Industrial preparation method of 3- [4- (2-methoxyphenyl) piperazine-1-yl ] propionitrile | 河北一品生物医药有限公司 | 2023-08-04 | — | — | CN | claimed |
| US-20230150924-A1 | NOVEL COMPOUND HAVING CANCER METASTASIS INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR INHIBITING CANCER METASTASIS AND INVASION OR TREATING COLORECTAL CANCER, COMPRISING COMPOUND | CELLGENTEK CO., LTD. (KR) | 2023-05-18 | — | — | US | claimed |
| CN-114644838-B | Method for preparing black phosphorus-piperazine compound composite material | 山东玥能新材料科技有限公司 | 2023-04-11 | — | — | CN | claimed |
| CN-112010822-B | Method for preparing chiral gamma-amino alcohol and chiral alpha-allyl alcohol by one-pot method | 南方科技大学 | 2022-11-18 | — | — | CN | claimed |
| CN-115108999-A | Phenyl piperazine quinazoline compound or pharmaceutically acceptable salt thereof, preparation method and application | 暨南大学 | 2022-09-27 | — | — | CN | claimed |
| CN-114920704-A | Phenyl piperazine quinazoline compound or pharmaceutically acceptable salt thereof, preparation method and application | 暨南大学 | 2022-08-19 | — | — | CN | claimed |
| CN-114685399-A | Preparation method of urapidil intermediate 1- (2-methoxyphenyl) piperazine and salt thereof | 河北广祥制药有限公司 | 2022-07-01 | — | — | CN | claimed |
| EP-4019495-A1 | NOVEL COMPOUND HAVING CANCER METASTASIS INHIBITORY ACTIVITY, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION FOR INHIBITING CANCER METASTASIS AND INVASION OR TREATING COLORECTAL CANCER, COMPRISING COMPOUND | Cellgentek Co., Ltd (KR) | 2022-06-29 | — | — | EP | claimed |
| EP-0120558-B1 | ANTIHYPERTENSIVE N-PIPERAZINYLALKANOYLANILIDES | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1989-03-08 | — | — | EP | claimed |
| EP-0272478-A1 | Glycyrrhetic acid derivatives and use thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1988-06-29 | — | — | EP | claimed |
| EP-0251194-A1 | Use of carbocyclic and heterocyclic condensed dihydropyridines for the preparation of cardioprotective remedies and heterocyclic and carbocyclic condensed dihydropyridines and methods and intermediates for their preparation | BOEHRINGER INGELHEIM KG (DE) | 1988-01-07 | — | — | EP | claimed |
| EP-0089065-B1 | NOVEL PHENYLPIPERAZINE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1987-06-16 | — | — | EP | claimed |
| EP-0120558-A1 | Antihypertensive N-piperazinylalkanoylanilides | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 1984-10-03 | — | — | EP | claimed |
| EP-0089065-A2 | Novel phenylpiperazine derivatives and process for producing the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1983-09-21 | — | — | EP | claimed |
| EP-0009655-B1 | 6-AMINO SUBSTITUTED N-PYRROLYL-3-PYRIDAZINE AMINES, THEIR PREPARATION, AND PHARMACEUTICALLY ANTIHYPERTENSIVE COMPOSITIONS CONTAINING THEM | GRUPPO LEPETIT S.P.A. (IT) | 1983-05-11 | — | — | EP | claimed |
| US-4247551-A | N-Pyrrolyl-pyridazineamines and their use as antihypertensive agents | GRUPPO LEPETIT S.P.A. (IT) | 1981-01-27 | — | — | US | claimed |
| EP-0009655-A1 | 6-Amino substituted N-pyrrolyl-3-pyridazine amines, their preparation, and pharmaceutically antihypertensive compositions containing them | GRUPPO LEPETIT S.P.A. (IT) | 1980-04-16 | — | — | EP | claimed |
| US-3933803-A | ANTIBACTERIAL, ANTIMITOTIC, ANTIMYCOTIC | INSTITUTO LUSO FARMACO D'ITALIA S.R.L. (IT) | 1976-01-20 | — | — | US | claimed |