Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789642 | 0.83 | AKR1B1 (0.39) | AKR1B1GPR139PDE10AALPGKDM4E | |
| SCHEMBL6474348 | 0.75 | ALDH1A1 (0.44) | KMT2AMAPTHTTALDH1A1GPR139 | |
| SCHEMBL3805799 | 0.72 | DDR1 (0.41) | KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL3783283 | 0.71 | KDM4C (0.45) | KMT2AMAPTALDH1A1MAPK1KDM4E | |
| SCHEMBL11469753 | 0.67 | GPR139 (0.38) | ALDH1A1MAPK1GPR139KDM4EGAA | |
| SCHEMBL22125842 | 0.62 | CYP1A2 (0.41) | KMT2AMAPTALOX15ALDH1A1MAPK1 | |
| SCHEMBL12986033 | 0.62 | L3MBTL1 (0.63) | KMT2AMAPTHTTALDH1A1MAPK1 | |
| SCHEMBL4846996 | 0.61 | BRD4 (0.41) | MAPTALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL3708402 | 0.60 | SCN5A (0.44) | KMT2AAKR1B1ALDH1A1ALPGKDM4E | |
| SCHEMBL11784467 | 0.60 | KMT2A (0.40) | KMT2AMAPTALOX15ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | claimed |
| WO-2010096722-A1 | 3-OXO-2, 3-DIHYDRO- [1,2, 4] TRIAZOLO [4, 3-A]PYRIDINES AS SOLUBLE EPOXIDE HYDROLASE (SEH) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | WO | disclosed |