Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3793868 | 0.87 | HPGD (0.47) | PIK3CA | |
| SCHEMBL3795344 | 0.77 | TDP1 (0.44) | PIK3CATDP1NPSR1HDAC3HDAC1 | |
| SCHEMBL3754632 | 0.76 | PIK3CA (0.72) | PIK3CA | |
| SCHEMBL24258525 | 0.73 | CREBBP (0.62) | PIK3CAHDAC2CREBBPGPR142 | |
| SCHEMBL3758479 | 0.71 | PIK3CA (0.61) | PIK3CACREBBP | |
| SCHEMBL3754744 | 0.71 | PIK3CA (0.63) | PIK3CA | |
| SCHEMBL3752612 | 0.71 | PIK3CA (0.63) | PIK3CA | |
| SCHEMBL2726184 | 0.69 | PIK3CA (0.71) | PIK3CACREBBPGPR142 | |
| SCHEMBL3748228 | 0.69 | PIK3CA (0.71) | PIK3CAGPR142 | |
| SCHEMBL21780433 | 0.69 | GPR142 (0.48) | PIK3CAGPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010118208-A1 | BENZOXAZEPIN-4- (5H) -YL DERIVATIVES AND THEIR USE TO TREAT CANCER | EXELIXIS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |