SCHEMBL379246

SCHEMBL379246

CC(=O)c1ccc(C#N)cc1.CC(C)(O)c1ccc(C#N)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.57
MAPT P10636 1/20 0.57
EPHX2 P34913 1/20 0.49
CA1 P00915 2/20 0.47
CA2 P00918 2/20 0.47
KIF11 P52732 1/20 0.46
GSK3B P49841 3/20 0.43
MLYCD O95822 2/20 0.43
PDK1 Q15118 1/20 0.43
PDK2 Q15119 1/20 0.43
PDK3 Q15120 1/20 0.43
PDK4 Q16654 1/20 0.43
RARB P10826 1/20 0.41
RARG P13631 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
HSD11B1 P28845 1/20 0.41
LMNA P02545 1/20 0.41
HRH2 P25021 1/20 0.40
HRH1 P35367 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL379565 0.85 KIF11 (0.59) ALDH1A1EPHX2CA1CA2KIF11
SCHEMBL548546 0.85 EPHX2 (0.49) ALDH1A1MAPTEPHX2KIF11MEN1
SCHEMBL163209 0.85 ALDH1A1 (0.72) ALDH1A1MAPTCA1CA2GSK3B
SCHEMBL22096338 0.83 ALDH1A1 (0.58) ALDH1A1MAPTEPHX2CA1CA2
Formaldehyde SCHEMBL27504509 0.81 ALDH1A1 (0.68) ALDH1A1MAPTCA1CA2GSK3B
SCHEMBL8363133 0.80 MAPT (0.57) ALDH1A1MAPTEPHX2KIF11MEN1
SCHEMBL4492464 0.80 MAPT (0.57) ALDH1A1MAPTEPHX2KIF11MEN1
SCHEMBL10058042 0.80 MAPT (0.66) ALDH1A1MAPTCA1CA2KIF11
Trifluoromethylbenzene SCHEMBL27882704 0.76 ALDH1A1 (0.53) ALDH1A1MAPTCA1CA2KIF11
SCHEMBL307335 0.74 EPHX2 (0.44) ALDH1A1MAPTEPHX2KIF11RARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408777-A1 IMPROVED CHEMICAL SYNTHESIS OF DIAZAINDOLES BY CHICHIBABIN CYCLIZATION SANOFI (FR) 2012-01-25 EP claimed
WO-2010107969-A1 IMPROVED CHEMICAL SYNTHESIS OF DIAZAINDOLES BY CHICHIBABIN CYCLIZATION SANOFI-AVENTIS (FR) 2010-09-23 WO claimed
EP-2408777-A1 IMPROVED CHEMICAL SYNTHESIS OF DIAZAINDOLES BY CHICHIBABIN CYCLIZATION SANOFI (FR) 2012-01-25 EP disclosed
WO-2010107969-A1 IMPROVED CHEMICAL SYNTHESIS OF DIAZAINDOLES BY CHICHIBABIN CYCLIZATION SANOFI-AVENTIS (FR) 2010-09-23 WO disclosed