SCHEMBL379345

SCHEMBL379345

O[Si](Cc1ccccc1)(Cc1ccccc1)Cc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.48
CALM1 P0DP23 1/20 0.45
TDP1 Q9NUW8 1/20 0.43
IDO1 P14902 2/20 0.42
THRB P10828 1/20 0.42
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
AKR1B1 P15121 1/20 0.42
ALDH1A1 P00352 2/20 0.41
LOXL2 Q9Y4K0 2/20 0.41
TP53 P04637 1/20 0.41
TRPA1 O75762 1/20 0.41
NR1H2 P55055 1/20 0.39
NR1H3 Q13133 1/20 0.39
MAOB P27338 1/20 0.39
HPGD P15428 1/20 0.39
ALOX15 P16050 1/20 0.39
ALOX12 P18054 1/20 0.39
CASP1 P29466 1/20 0.39
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3503476 0.85 TP53 (0.46) TSHRCALM1TDP1IDO1THRB
SCHEMBL9622630 0.82 TSHR (0.48) TSHRCALM1TDP1IDO1THRB
SCHEMBL4526742 0.82 TSHR (0.48) TSHRCALM1TDP1IDO1THRB
SCHEMBL15302578 0.79 GAA (0.36) TSHRCALM1TDP1IDO1THRB
SCHEMBL2290902 0.79 GAA (0.36) TSHRCALM1TDP1IDO1THRB
SCHEMBL679387 0.78 TSHR (0.43) TSHRCALM1TDP1IDO1THRB
SCHEMBL28136682 0.78 TSHR (0.43) TSHRCALM1TDP1IDO1THRB
SCHEMBL4514772 0.78 TSHR (0.43) TSHRCALM1TDP1IDO1THRB
SCHEMBL3481784 0.78 TSHR (0.43) TSHRCALM1TDP1IDO1THRB
SCHEMBL15302661 0.77 TSHR (0.48) TSHRCALM1TDP1IDO1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 362 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2776382-B1 18F-SACCHARIDE-FOLATES Merck & Cie (CH) 2018-09-19 EP claimed
EP-2308861-B1 MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS EISAI R&D MAN CO LTD (JP) 2017-03-01 EP claimed
EP-1910387-B1 COMPOUNDS FOR PREPARING IMMUNOLOGICAL ADJUVANT EISAI R&D MAN CO LTD (JP) 2016-11-16 EP claimed
EP-2427057-B1 BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS SLOAN KETTERING INST CANCER (US) 2015-08-12 EP claimed
EP-2049689-B1 NUCLEIC ACID AMPLIFICATION USING A REVERSIBLY MODIFIED OLIGONUCLEOTIDE BI WANLI (US) 2011-12-21 EP claimed
EP-1149086-B1 NOVEL PROCESS FOR THE REMOVAL OF A SILYLOXY PROTECTING GROUP FROM 4-SILYLOXY-TETRAHYDRO-PYRAN-2-ONES LEK TOVARNA FARMACEVTSKIH (SI) 2004-05-12 EP claimed
EP-0352715-B1 Twice-aged porous inorganic oxides, catalysts, and polymerization processes CONOCOPHILLIPS CO (US) 2003-11-19 EP claimed
EP-1132130-B1 Twice-aged porous inorganic oxides, catalysts, and polymerization processes CONOCOPHILLIPS CO (US) 2003-07-02 EP claimed
CN-1088621-C Chromium-containing catalyst PHILLIPS PETROLEUM CO (US) 2002-08-07 CN claimed
EP-1149086-A1 NOVEL PROCESS FOR THE REMOVAL OF A SILYLOXY PROTECTING GROUP FROM 4-SILYLOXY-TETRAHYDRO-PYRAN-2-ONES Lek Pharmaceutical and Chemical Co. D.D. (SI) 2001-10-31 EP claimed
US-5650523-A REACTION IN SOLVENTS TO FORM HYDROXY GROUPS MERCK & CO., INC. (US) 1997-07-22 US claimed
EP-0444888-B1 Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one MERCK & CO INC (US) 1995-02-08 EP claimed
US-5115053-A Aging, spray drying and adding a chromium compound to produce a polymerization catalyst for olefins PHILLIPS PETROLEUM COMPANY (US) 1992-05-19 US claimed
EP-0444888-A1 Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one MERCK & CO. INC. (US) 1991-09-04 EP claimed
US-4981831-A NEUTRAL AND ALKALINE AGING PHILLIPS PETROLEUM COMPANY (US) 1991-01-01 US claimed
CN-1039779-A Twice aged porous inorganic oxides, catalysts and polymerization processes PHILLIPS PETROLEUM CO (US) 1990-02-21 CN claimed
EP-0352715-A1 Twice-aged porous inorganic oxides, catalysts, and polymerization processes PHILLIPS PETROLEUM COMPANY (US) 1990-01-31 EP claimed
US-4886788-A Cyclodextrin clathrates of carbacyclin derivatives and their use as medicinal agents SCHERING AKTIENGESELLSCHAFT (DE) 1989-12-12 US claimed
US-4190457-A CONTACTING WITH ORGANOSILICON COMPOUND, DRYING, INCREASING PORE VOLUME PHILLIPS PETROLEUM CO. (US) 1980-02-26 US claimed
US-4180672-A 2-Organothio-2-cyclopentenones, organothio-cyclopentanes derived therefrom TEIJIN LIMITED (JP) 1979-12-25 US claimed