Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3791360 | 0.91 | DHFR (0.34) | DHFR | |
| SCHEMBL3794538 | 0.90 | CYP2D6 (0.32) | DHFR | |
| SCHEMBL3791152 | 0.89 | DHFR (0.34) | DHFRGAAPKM | |
| SCHEMBL3795976 | 0.89 | PDE10A (0.34) | DHFRGAA | |
| SCHEMBL3795926 | 0.86 | NPC1 (0.37) | GAAPIK3CAPIK3CBPIK3CGUSP2 | |
| SCHEMBL1708131 | 0.83 | FFAR1 (0.38) | USP2PKM | |
| SCHEMBL10292325 | 0.83 | FFAR1 (0.38) | USP2PKM | |
| SCHEMBL10291346 | 0.82 | LMNA (0.39) | USP2PKM | |
| SCHEMBL1708368 | 0.82 | LMNA (0.33) | GAAPIK3CAPIK3CBPIK3CGUSP2 | |
| SCHEMBL1707938 | 0.81 | DHFR (0.39) | DHFRPIK3CAPIK3CBPIK3CGUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |