Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.31 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.31 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708060 | 0.92 | MAPT (0.32) | SMN1; SMN2MAPTTRPV1HTTGAA | |
| SCHEMBL1708304 | 0.92 | MAPT (0.32) | LMNAMAPTUSP2PKMMEN1 | |
| SCHEMBL1708079 | 0.91 | ALOX5AP (0.33) | TRPV1MDM2 | |
| SCHEMBL1708237 | 0.91 | APLNR (0.34) | MAPTPKMMEN1KMT2AGAA | |
| SCHEMBL1708420 | 0.90 | L3MBTL1 (0.36) | LMNAMAPTTSHRNPSR1MAPK1 | |
| SCHEMBL1708131 | 0.89 | FFAR1 (0.38) | LMNASMN1; SMN2MAPTTSHRNPSR1 | |
| SCHEMBL10292325 | 0.89 | FFAR1 (0.38) | LMNASMN1; SMN2MAPTTSHRNPSR1 | |
| SCHEMBL10291346 | 0.88 | LMNA (0.39) | LMNASMN1; SMN2MAPTTSHRNPSR1 | |
| SCHEMBL3794485 | 0.82 | DHFR (0.33) | USP2PKMPIK3CAPIK3CBPIK3CG | |
| SCHEMBL10009394 | 0.80 | FFAR1 (0.39) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |