Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | NT5E | P21589 | 2/20 | 0.31 |
| ▸ | PTGES | O14684 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3799835 | 0.89 | PTGES (0.45) | NT5EPTGESJAK2 | |
| SCHEMBL3803127 | 0.81 | JAK2 (0.36) | HPGDAHRNT5EPTGESJAK2 | |
| SCHEMBL14692185 | 0.79 | NT5E (0.31) | NT5EPTGES | |
| SCHEMBL31254853 | 0.76 | EGLN2 (0.33) | — | |
| SCHEMBL11623789 | 0.75 | HPGD (0.43) | HPGDNT5EPOLB | |
| SCHEMBL31254733 | 0.74 | TTR (0.36) | HPGDTTR | |
| SCHEMBL649565 | 0.74 | HPGD (0.56) | HPGDMAPK14POLBNPSR1 | |
| SCHEMBL26093883 | 0.73 | KDM4E (0.44) | HPGDCSNK1DMAPK14NT5EPOLB | |
| SCHEMBL29079309 | 0.72 | GABRA1 (0.45) | HPGDAHRNPSR1 | |
| SCHEMBL27642887 | 0.71 | SCN2A (0.51) | HPGDMAPK14NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |