Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1356582 | 0.71 | CA1 (0.41) | LMNACES2CES1AKR1B1SMN1; SMN2 | |
| SCHEMBL3900187 | 0.71 | CA1 (0.41) | SMN1; SMN2ALDH1A1CA1CA2L3MBTL1 | |
| SCHEMBL2836728 | 0.71 | CA1 (0.38) | CES2CES1AKR1B1SMN1; SMN2ALDH1A1 | |
| Diphenylmethane SCHEMBL11255043 | 0.69 | PLA2G10 (0.59) | LMNAPLA2G10PLA2G2AALDH1A1NPC1 | |
| SCHEMBL56273 | 0.69 | ORAI1 (0.42) | LMNACES2CES1AKR1B1PARP10 | |
| SCHEMBL3887273 | 0.69 | TSHR (0.46) | LMNACYP1A2ALDH1A1HIF1APTGS1 | |
| SCHEMBL23535576 | 0.68 | LIPE (0.39) | LMNASMN1; SMN2ALDH1A1NPC1RAB9A | |
| Benzyl Carbamate SCHEMBL8592590 | 0.68 | ALDH1A1 (0.64) | LMNAPARP10ALDH1A1NPC1RAB9A | |
| Benzyl Carbamate SCHEMBL1697 | 0.67 | ALDH1A1 (0.63) | LMNAPARP10PKMSMN1; SMN2CYP1A2 | |
| Benzyl Carbamate SCHEMBL10700633 | 0.67 | ALDH1A1 (0.63) | LMNAPARP10PKMSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222638-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | Decode Genetics EHF (IS) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |