Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 16/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3794879 | 0.89 | PTGES (0.47) | PTGESJAK2ORAI1JAK3PIM1 | |
| SCHEMBL3802996 | 0.87 | PTGES (0.43) | PTGESJAK2 | |
| SCHEMBL3796320 | 0.85 | PTGES (0.49) | PTGESJAK2ORAI1JAK3PIM1 | |
| SCHEMBL29662800 | 0.84 | PTGES (0.43) | PTGESJAK2JAK3 | |
| SCHEMBL13076230 | 0.84 | PTGES (0.43) | PTGESJAK2JAK3 | |
| SCHEMBL13076361 | 0.82 | PTGES (0.53) | PTGESJAK2 | |
| SCHEMBL3795491 | 0.81 | PTGES (0.43) | PTGESJAK2 | |
| SCHEMBL3801417 | 0.81 | PTGES (0.48) | PTGESJAK2JAK3 | |
| SCHEMBL13076235 | 0.80 | PTGES (0.49) | PTGESJAK2 | |
| SCHEMBL3795385 | 0.79 | PTGES (0.40) | PTGESJAK2ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |