Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 5/20 | 0.52 |
| ▸ | HPGDS | O60760 | 6/20 | 0.48 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13076187 | 0.82 | PTGES (0.44) | PTGESORAI1JAK2MEN1HTT | |
| SCHEMBL3798806 | 0.80 | PTGES (0.42) | PTGESORAI1JAK2MEN1HTT | |
| SCHEMBL3799446 | 0.79 | PTGES (0.52) | PTGESHPGDSORAI1NPY5RJAK2 | |
| SCHEMBL3795476 | 0.75 | PTGES (0.60) | PTGESHPGDSORAI1JAK2SCN2A | |
| SCHEMBL3795312 | 0.73 | PTGES (0.49) | PTGESHPGDSORAI1NPY5RJAK2 | |
| SCHEMBL3794463 | 0.73 | PTGES (0.67) | PTGESHPGDSORAI1JAK2SCN2A | |
| SCHEMBL3794732 | 0.71 | PTGES (0.41) | PTGESORAI1JAK2 | |
| SCHEMBL3796195 | 0.69 | PTGES (0.50) | PTGESHPGDSORAI1JAK2SCN2A | |
| SCHEMBL13075538 | 0.69 | PTGES (0.49) | PTGESHPGDSJAK2MEN1KMT2A | |
| SCHEMBL3792008 | 0.68 | PTGES (0.62) | PTGESHPGDSJAK2SCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | claimed |