Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 6/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | HPGDS | O60760 | 2/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3795476 | 0.90 | PTGES (0.60) | PTGESSCN2AORAI1JAK2LTA4H | |
| SCHEMBL3795312 | 0.82 | PTGES (0.49) | PTGESSCN2AORAI1JAK2DGAT1 | |
| SCHEMBL13076592 | 0.82 | ORAI1 (0.41) | PTGESORAI1DGAT1MAPK10 | |
| SCHEMBL3797348 | 0.79 | PTGES (0.52) | PTGESSCN2AORAI1JAK2NPY5R | |
| SCHEMBL3794463 | 0.77 | PTGES (0.67) | PTGESSCN2AORAI1JAK2HPGDS | |
| SCHEMBL3792008 | 0.73 | PTGES (0.62) | PTGESSCN2AJAK2HPGDS | |
| SCHEMBL3790964 | 0.72 | PTGES (0.43) | PTGESORAI1JAK2DGAT1LTA4H | |
| SCHEMBL3800830 | 0.71 | PTGES (0.54) | PTGESSCN2AJAK2DGAT1NPY5R | |
| SCHEMBL18255789 | 0.71 | SYK (0.48) | PTGES | |
| SCHEMBL3797105 | 0.70 | PTGES (0.55) | PTGESSCN2AORAI1JAK2HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |