Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 6/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.37 |
| ▸ | HPGDS | O60760 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3791357 | 0.89 | PTGES (0.56) | PTGESSCN2AJAK2HPGDSNPY5R | |
| SCHEMBL3799446 | 0.82 | PTGES (0.52) | PTGESSCN2AJAK2ORAI1HPGDS | |
| SCHEMBL3800830 | 0.73 | PTGES (0.54) | PTGESSCN2AJAK2HPGDSDGAT1 | |
| SCHEMBL3795476 | 0.73 | PTGES (0.60) | PTGESSCN2AJAK2ORAI1HPGDS | |
| SCHEMBL3794463 | 0.73 | PTGES (0.67) | PTGESSCN2AJAK2ORAI1HPGDS | |
| SCHEMBL3797348 | 0.73 | PTGES (0.52) | PTGESSCN2AJAK2ORAI1HPGDS | |
| SCHEMBL3802070 | 0.71 | PTGES (0.49) | PTGESJAK2HPGDSNPY5R | |
| SCHEMBL3793690 | 0.71 | PTGES (0.46) | PTGESJAK2HPGDSDGAT1SCN10A | |
| SCHEMBL3795117 | 0.71 | PTGES (0.54) | PTGESJAK2ORAI1HPGDSMEN1 | |
| SCHEMBL3793877 | 0.69 | PTGES (0.55) | PTGESSCN2AJAK2HPGDSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127152-A2 | COMPOUNDS AND COMPOSITIONS AS MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 INHIBITORS | IRM LLC (BM) | 2010-11-04 | — | — | WO | disclosed |