Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.59 |
| ▸ | NQO2 | P16083 | 5/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.48 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3793596 | 1.00 | PPARG (0.59) | PPARGNQO2PARP10PARP3ALDH1A1 | |
| SCHEMBL3793593 | 1.00 | PPARG (0.59) | PPARGNQO2PARP10PARP3ALDH1A1 | |
| SCHEMBL12631347 | 0.89 | PPARG (0.52) | PPARGNQO2ALDH1A1MAPTMEN1 | |
| SCHEMBL12631326 | 0.89 | PPARG (0.52) | PPARGNQO2ALDH1A1MAPTMEN1 | |
| SCHEMBL4890342 | 0.88 | ALDH1A1 (0.54) | PPARGNQO2PARP10PARP3ALDH1A1 | |
| SCHEMBL4890340 | 0.88 | ALDH1A1 (0.54) | PPARGNQO2PARP10PARP3ALDH1A1 | |
| SCHEMBL3794641 | 0.85 | PPARG (0.65) | PPARGNQO2ALDH1A1MAPTLMNA | |
| SCHEMBL4928599 | 0.85 | PPARG (0.65) | PPARGNQO2ALDH1A1MAPTLMNA | |
| SCHEMBL13372018 | 0.84 | PPARG (0.64) | PPARGNQO2ALDH1A1MAPTLMNA | |
| SCHEMBL3793581 | 0.84 | PPARG (0.64) | PPARGNQO2ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718682-B2 | Heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718682-B2 | Heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-7718682-B2 | Heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-20080293949-A1 | Novel heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293949-A1 | Novel heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293949-A1 | Novel heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2008-11-27 | — | — | US | disclosed |
| US-7407978-B2 | Heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| US-7407978-B2 | Heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| US-20060235062-A1 | Novel heterocyclic analogs of diphenylethylene compounds | THERACOS, INC. (US) | 2006-10-19 | — | — | US | disclosed |
| EP-1549625-A1 | NOVEL HETEROCYCLIC ANALOGS OF DIPHENYLETHYLENE COMPOUNDS | Theracos, Inc. (US) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004033438-A1 | NOVEL HETEROCYCLIC ANALOGS OF DIPHENYLETHYLENE COMPOUNDS | THERACOS, INC. (US) | 2004-04-22 | — | — | WO | disclosed |
| US-20030181494-A1 | Novel heterocyclic analogs of diphenylethylene compounds | SEED, BRIAN | 2003-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181494-A1 | Novel heterocyclic analogs of diphenylethylene compounds | FFAR2, FFAR4, GPR119 | PPARG 10/4885NQO2 1897/4885PARP10 4609/4885 |
| US-20060235062-A1 | Novel heterocyclic analogs of diphenylethylene compounds | FFAR2, FFAR4, GPR119 | PPARG 10/4885NQO2 1897/4885PARP10 4609/4885 |
| US-20080293949-A1 | Novel heterocyclic analogs of diphenylethylene compounds | FFAR2, FFAR4, GPR119 | PPARG 10/4885NQO2 1897/4885PARP10 4609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.