SCHEMBL3798210

SCHEMBL3798210

NC[C@H]1CN(c2ccccc2)C(=O)O1

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 14/20 0.69
F10 P00742 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5007547 1.00 GRM2 (0.69) GRM2F10
SCHEMBL9550277 0.91 F10 (0.60) GRM2F10
SCHEMBL9844322 0.87 GRM2 (0.69) GRM2
SCHEMBL14168239 0.87 F10 (0.66) GRM2F10
SCHEMBL12728922 0.84 GRM2 (0.64) GRM2F10
SCHEMBL28767300 0.84 F10 (0.63) GRM2F10
SCHEMBL3328770 0.84 F10 (0.63) GRM2F10
SCHEMBL21297020 0.84 F10 (0.59) GRM2F10
SCHEMBL9823520 0.84 F10 (0.63) GRM2F10
SCHEMBL15203256 0.84 GRM2 (0.64) GRM2F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2722330-B1 NOVEL METHOD FOR SYNTHESIZING RIVAROXABAN INTERMEDIATE, 4-{4-[(5S)-5-(AMINOMETHYL)-2-OXO-1,3-OXAZOLIDIN-3-YL]PHENYL}MORPHOLIN-3-ONE ZHEJIANG HUAHAI PHARM CO LTD (CN) 2017-04-26 EP claimed
EP-2722330-A1 NOVEL METHOD FOR SYNTHESIZING RIVAROXABAN INTERMEDIATE, 4-{4-[(5S)-5-(AMINOMETHYL)-2-OXO-1,3-OXAZOLIGDIN-3-YL]PHENYL}MORPHOLIN-3-ONE Zhejiang Huahai Pharmaceutical Co., Ltd. (CN) 2014-04-23 EP claimed
EP-0434714-A1 IN POSITION 3 SUBSTITUTED-5-BETA-AMIDOMETHYL-OXAZOLIDIN-2-ONES THE UPJOHN COMPANY (US) 1991-07-03 EP claimed
WO-1990002744-A1 IN POSITION 3 SUBSTITUTED-5-BETA-AMIDOMETHYL-OXAZOLIDIN-2-ONES THE UPJOHN COMPANY (US) 1990-03-22 WO claimed
US-9376427-B2 Process for preparing rivaroxaban using intermediates SYMED LABS LIMITED (IN) 2016-06-28 US disclosed
US-20150126733-A1 IMPROVED PROCESS FOR PREPARING RIVAROXABAN USING NOVEL INTERMEDIATES SYMED LABS LIMITED (IN) 2015-05-07 US disclosed
WO-2014155259-A2 PROCESS FOR THE PREPARATION OF RIVAROXABAN GLENMARK PHARMACEUTICALS LIMITED; GLENMARK GENERICS LIMITED (IN) 2014-10-02 WO disclosed
WO-2013027225-A1 PROCESSES FOR THE PREPARATION OF 4-{4-[5(S)-(AMINOMETHYL)-2-OXO-1,3-OXAZOLIDIN-3-YL]PHENYL} MORPHOLIN-3-ONE SYMED LABS LIMITED (IN) 2013-02-28 WO disclosed
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LTD. (IN) 2010-11-25 US disclosed
WO-2008143649-A2 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS DR. REDDY'S LABORATORIES LIMITED (IN) 2008-11-27 WO disclosed
US-20080214565-A1 Oxazolidinone Derivatives as Antimicrobials RANBAXY LABORATORIES LIMITED (IN) 2008-09-04 US disclosed
US-20060293307-A1 Oxazolidinone derivatives as antimicrobials RANBAXY LABORATORIES LIMITED (IN) 2006-12-28 US disclosed
WO-2004069816-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LABORATORIES LIMITED (IN) 2004-08-19 WO disclosed
US-6734307-B2 USE AGAINST MULTIPLY RESISTANT GRAM POSITIVE PATHOGENS; HAVE A DIAZINE MOIETY ATTACHED TO THE PHENYLOXAZOLIDINONE WHICH IS FURTHER SUBSTITUTED BY HETEROCYCLIC, ARYL, SUBSTITUTED ARYL, HETEROAROAMATIC RING RANBAXY LABORATORIES LIMITED (IN) 2004-05-11 US disclosed
WO-2004014392-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LABORATORIES LIMITED (IN) 2004-02-19 WO disclosed
US-20030119817-A1 Oxazolidinone derivatives as potential antimicrobials MEHTA ANITA (IN) 2003-06-26 US disclosed
EP-1303511-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LABORATORIES, LTD. (IN) 2003-04-23 EP disclosed
US-20020103186-A1 Oxazolidinone derivatives as antimicrobials disease RANBAXY LABORATORIES LIMITED (IN) 2002-08-01 US disclosed
WO-2002006278-A1 OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS RANBAXY LABORATORIES LIMITED (IN) 2002-01-24 WO disclosed
US-6069160-A Heteroatom-containing benzocyclopentane-oxazolidinones BAYER AKTIENGESELLSCHAFT (DE) 2000-05-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030119817-A1 Oxazolidinone derivatives as potential antimicrobials OXA1L, PDK4, SDHA GRM2 3938/4885F10 1559/4885
US-20150126733-A1 IMPROVED PROCESS FOR PREPARING RIVAROXABAN USING NOVEL INTERMEDIATES SULT1E1, CYP2C9, VKORC1 GRM2 1685/4885F10 194/4885
US-20020103186-A1 Oxazolidinone derivatives as antimicrobials disease OXA1L, MLYCD, TBCD GRM2 4151/4885F10 836/4885
US-20060293307-A1 Oxazolidinone derivatives as antimicrobials OXA1L, PDK4, SDHA GRM2 3672/4885F10 1403/4885
US-20080214565-A1 Oxazolidinone Derivatives as Antimicrobials OXA1L, SDHA, PDK4 GRM2 4111/4885F10 1210/4885
US-20100298384-A1 NOVEL OXAZOLIDINONE COMPOUNDS AS ANTIINFECTIVE AGENTS OXA1L, MIF, VIP GRM2 2504/4885F10 4714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.