Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 5/20 | 0.39 |
| ▸ | HTR2C | P28335 | 5/20 | 0.39 |
| ▸ | HTR2B | P41595 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8498091 | 0.84 | CAPN1 (0.53) | CAPN1MMP2ANPEPHTR2AHTR2C | |
| SCHEMBL10851353 | 0.84 | CAPN1 (0.53) | CAPN1MMP2ANPEPHTR2AHTR2C | |
| SCHEMBL3804693 | 0.82 | SMN1; SMN2 (0.47) | CAPN1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3566060 | 0.78 | NPC1 (0.41) | CAPN1MMP2ANPEPRAB9ANPC1 | |
| SCHEMBL13545530 | 0.73 | CHEK1 (0.46) | MMP2ANPEP | |
| SCHEMBL12992250 | 0.73 | CHEK1 (0.46) | MMP2ANPEP | |
| SCHEMBL29177033 | 0.71 | CHEK1 (0.47) | MMP2ANPEPDRD2DRD4 | |
| SCHEMBL1000380 | 0.71 | ACHE (0.51) | RAB9AACHESMN1; SMN2 | |
| SCHEMBL29476747 | 0.71 | ACHE (0.51) | RAB9AACHESMN1; SMN2 | |
| SCHEMBL5847274 | 0.70 | DRD2 (0.48) | MMP2ANPEPDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234487-A1 | ANILIDES AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-10-06 | — | — | EP | disclosed |
| WO-2009079009-A1 | ANILIDES AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |