Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10851353 | 1.00 | CAPN1 (0.53) | CAPN1HTR2AHTR2CHTR2BMMP2 | |
| SCHEMBL3799179 | 0.84 | CAPN1 (0.41) | CAPN1HTR2AHTR2CHTR2BMMP2 | |
| SCHEMBL8498408 | 0.83 | CAPN1 (0.56) | CAPN1HTR2AHTR2CHTR2BTSHR | |
| SCHEMBL10855534 | 0.83 | CAPN1 (0.56) | CAPN1HTR2AHTR2CHTR2BTSHR | |
| SCHEMBL10854074 | 0.83 | CAPN1 (0.56) | CAPN1HTR2AHTR2CHTR2BTSHR | |
| SCHEMBL5847274 | 0.80 | DRD2 (0.48) | MMP2ANPEPTSHRDRD2DRD4 | |
| SCHEMBL5847272 | 0.80 | DRD2 (0.48) | MMP2ANPEPTSHRDRD2DRD4 | |
| SCHEMBL5847276 | 0.80 | DRD2 (0.48) | MMP2ANPEPTSHRDRD2DRD4 | |
| SCHEMBL3566060 | 0.79 | NPC1 (0.41) | CAPN1MMP2ANPEPRAB9A | |
| SCHEMBL12992250 | 0.77 | CHEK1 (0.46) | MMP2ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952328-A | MAY BE USED TO ALLEVIATE, MEDIATE, REDUCE AND/OR PREVENT DISORDERS WHICH ARE ASSOCIATED WITH ABNORMAL AND/OR ABERRANT ACTIVITY OF CYSTEINE PROTEASES AND/OR SERINE PROTEASES | CEPHALON, INC. (US) | 1999-09-14 | — | — | US | disclosed |
| US-4563306-A | CONSCIOUSNESS DISORDERS | TANABE SEIYAKU CO., LTD. (JP) | 1986-01-07 | — | — | US | disclosed |
| EP-0134582-A2 | Novel peptides and process for preparing the same and pharmaceutical composition | Tanabe Seiyaku Co., Ltd. (JP) | 1985-03-20 | — | — | EP | disclosed |