Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13228175 | 0.86 | PTGS2 (0.52) | PTGS2ALDH1A1TDP1 | |
| SCHEMBL3800825 | 0.81 | PTGS2 (0.63) | PTGS2 | |
| SCHEMBL3791819 | 0.81 | PTGS2 (0.63) | PTGS2 | |
| SCHEMBL3801351 | 0.81 | PTGS2 (0.63) | PTGS2 | |
| SCHEMBL3792799 | 0.80 | PTGS2 (0.78) | PTGS2 | |
| SCHEMBL9311171 | 0.78 | ALDH1A1 (0.65) | PTGS2ALDH1A1TDP1ADAMTS4ERN1 | |
| SCHEMBL3800269 | 0.78 | PTGS2 (0.59) | PTGS2 | |
| SCHEMBL13261508 | 0.77 | ALDH1A1 (0.37) | PTGS2ALDH1A1TDP1PTPN1PTPRC | |
| SCHEMBL6532977 | 0.74 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL3791856 | 0.73 | PTGS2 (0.67) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781592-B2 | Thione derivative, method for the preparation thereof, and pharmaceutical composition containing the same | CJ CHEILJEDANG CORPORATION (KR) | 2010-08-24 | — | — | US | claimed |
| US-20080090875-A1 | Thione Derivative, Method For The Preparation Thereof, And Pharmaceutical Composition Containing The Same | CJC CORPORATION (KR) | 2008-04-17 | — | — | US | claimed |
| WO-2005051941-A1 | THIONE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | CJ CORPORATION (KR) | 2005-06-09 | — | — | WO | claimed |
| US-7781592-B2 | Thione derivative, method for the preparation thereof, and pharmaceutical composition containing the same | CJ CHEILJEDANG CORPORATION (KR) | 2010-08-24 | — | — | US | disclosed |
| US-20080090875-A1 | Thione Derivative, Method For The Preparation Thereof, And Pharmaceutical Composition Containing The Same | CJC CORPORATION (KR) | 2008-04-17 | — | — | US | disclosed |
| WO-2005051941-A1 | THIONE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | CJ CORPORATION (KR) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090875-A1 | Thione Derivative, Method For The Preparation Thereof, And Pharmaceutical Composition Containing The Same | TPMT, TST, CYP3A5 | PTGS2 922/4885ALDH1A1 248/4885TDP1 207/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.