SCHEMBL3799465

SCHEMBL3799465

CC(c1ccccc1)[Si](C)(C)Cl

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 1/20 0.43
ADRA2C P18825 1/20 0.43
LMNA P02545 1/20 0.43
HIF1A Q16665 1/20 0.43
KDM4E B2RXH2 1/20 0.43
TSHR P16473 1/20 0.42
ALDH1A1 P00352 1/20 0.41
AOC3 Q16853 1/20 0.40
TAAR1 Q96RJ0 4/20 0.39
CYP2D6 P10635 1/20 0.38
TRPA1 O75762 1/20 0.36
DPP4 P27487 2/20 0.36
F2 P00734 1/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6671378 0.87 TSHR (0.43) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL208902 0.82 TSHR (0.43) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL7769306 0.82 TSHR (0.43) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL7795647 0.82 TSHR (0.43) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL6420857 0.79 TAAR1 (0.42) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL3195038 0.77 GABRA1 (0.37) LMNAHIF1ATSHRALDH1A1CYP2D6
SCHEMBL7765413 0.76 TSHR (0.39) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL4951403 0.75 TYR (0.44) ADRA2AADRA2CLMNAHIF1AKDM4E
SCHEMBL4086098 0.75 TSHR (0.48) ADRA2AADRA2CLMNATSHRAOC3
SCHEMBL4050988 0.75 TAAR1 (0.39) ADRA2AADRA2CLMNAHIF1AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010113188-A1 FLUORURATED SILICONIC POLYMER, SYNTHESIS METHOD AND USE MAFLON S.R.L. (IT) 2010-10-07 WO claimed
US-6822109-B2 TRIHYDROCARBYLSILYLATION; ADDITION POLYMERIZATION OF OLEFINS CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2004-11-23 US claimed
US-20040106814-A1 Silicon ether compound, a method for the preparation thereof and use thereof BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2004-06-03 US claimed
CN-114144388-A Systems and methods for manufacturing water-based hydrophobic aerogels and aerogel composites 克罗斯林克私人有限公司 2022-03-04 CN disclosed
WO-2019178871-A1 HIGH-TEMPERATURE RESISTANT POLYESTER COMPOSITE MATERIAL AND PREPARATION METHOD THEREOF 南通纺织丝绸产业技术研究院 2019-09-26 WO disclosed
US-10179840-B2 Condensation curable resin composition and semiconductor package SHIN-ETSU CHEMICAL CO., LTD. (JP) 2019-01-15 US disclosed
US-20170306098-A1 CONDENSATION CURABLE RESIN COMPOSITION AND SEMICONDUCTOR PACKAGE SHIN-ETSU CHEMICAL CO., LTD. (JP) 2017-10-26 US disclosed
US-9751989-B2 Condensation curable resin composition and semiconductor package SHIN-ETSU CHEMICAL CO., LTD. (JP) 2017-09-05 US disclosed
WO-2010113188-A1 FLUORURATED SILICONIC POLYMER, SYNTHESIS METHOD AND USE MAFLON S.R.L. (IT) 2010-10-07 WO disclosed
WO-2005111114-A1 PROTON-CONDUCTIVE CROSS-LINKED POLYSILOXANE WITH HETEROATOM-CONTAINING FUNCTIONAL GROUPS IN THE SIDE CHAIN, PROTON-CONDUCTIVE MEMBRANE AND METHOD FOR THE PRODUCTION THEREOF UNIVERSITÄT BREMEN (DE) 2005-11-24 WO disclosed
US-6822109-B2 TRIHYDROCARBYLSILYLATION; ADDITION POLYMERIZATION OF OLEFINS CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2004-11-23 US disclosed
CN-1540776-A Method of mfg. organic transistor and organic transistor �ձ������ȷ湫˾ 2004-10-27 CN disclosed
EP-1266903-B1 Method of preparing an organosilicon compound DOW CORNING ASIA LTD (JP) 2004-09-29 EP disclosed
US-20040106814-A1 Silicon ether compound, a method for the preparation thereof and use thereof BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2004-06-03 US disclosed
EP-1266903-A1 Method of preparing an organosilicon compound DOW CORNING ASIA, Ltd. (JP) 2002-12-18 EP disclosed
US-6326506-B1 HYDROSILATION DOW CORNING ASIA, LTD. (JP) 2001-12-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040106814-A1 Silicon ether compound, a method for the preparation thereof and use thereof SIK1, CDK20, SGMS1 ADRA2A 3861/4885ADRA2C 2581/4885LMNA 3094/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.