Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28926555 | 0.76 | TSHR (0.39) | ALDH1A1HPGDHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL7218289 | 0.72 | POLB (0.45) | MAPTALDH1A1KMT2APOLBRAB9A | |
| SCHEMBL16828925 | 0.71 | PARP1 (0.46) | MAPTALDH1A1HPGDHSD17B10KDM4E | |
| SCHEMBL4623246 | 0.67 | MAPT (0.50) | MAPTALDH1A1HPGDPOLBNPC1 | |
| SCHEMBL8785200 | 0.67 | IDO1 (0.32) | — | |
| SCHEMBL483417 | 0.67 | GAA (0.46) | ALDH1A1KMT2AHPGDPOLBNPC1 | |
| SCHEMBL22979909 | 0.67 | RAB9A (0.44) | MAPTALDH1A1KMT2AHPGDPOLB | |
| SCHEMBL30402134 | 0.67 | MAPT (0.44) | MAPTALDH1A1KMT2AHPGDPOLB | |
| SCHEMBL8022680 | 0.66 | IDO1 (0.31) | — | |
| SCHEMBL3473060 | 0.66 | MEN1 (0.45) | KMT2ANPC1RAB9AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139888-A2 | IMIDAZOÝ1,2-A¨PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008121687-A2 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-10-09 | — | — | WO | disclosed |