Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19798741 | 0.84 | MAPK1 (0.69) | MAPK1TSHRLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL13543488 | 0.79 | ALDH1A1 (0.69) | MEP1BMAPK1TSHRLMNASMN1; SMN2 | |
| SCHEMBL7673440 | 0.78 | MEP1B (0.60) | MEP1BTSHRF2LMNAALDH1A1 | |
| SCHEMBL751320 | 0.77 | MEP1B (0.52) | MEP1BMAPK1TSHRF2SMN1; SMN2 | |
| SCHEMBL9263017 | 0.77 | ALDH1A1 (0.59) | MEP1BMAPK1TSHRLMNASMN1; SMN2 | |
| SCHEMBL9414192 | 0.76 | MEN1 (0.65) | MEP1BMAPK1TSHRALDH1A1GAA | |
| SCHEMBL23787605 | 0.76 | MEP1B (0.65) | MEP1BMAPK1TSHRLMNASMN1; SMN2 | |
| SCHEMBL7669283 | 0.75 | MEP1B (0.58) | MEP1BTSHRF2SMN1; SMN2ALDH1A1 | |
| SCHEMBL1018445 | 0.75 | CYP2C19 (0.67) | MEP1BTSHRF2LMNAALDH1A1 | |
| SCHEMBL3103190 | 0.74 | MEP1B (0.67) | MEP1BTSHRLMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183239-A1 | SULFONAMIDES AS TRPM8 MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009012430-A1 | SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-22 | — | — | WO | disclosed |