Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | PTPRC | P08575 | 2/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667880 | 0.90 | LMNA (0.54) | MEP1BALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7673504 | 0.87 | ALDH1A1 (0.54) | MEP1BGAAALDH1A1KDM4ENPC1 | |
| SCHEMBL28588397 | 0.87 | ALDH1A1 (0.51) | MEP1BGAAALDH1A1KDM4ENPC1 | |
| SCHEMBL7673440 | 0.86 | MEP1B (0.60) | MEP1BALDH1A1TSHRF2TMPRSS6 | |
| SCHEMBL19450297 | 0.84 | MMP2 (0.56) | MEP1BGAAALDH1A1KDM4ENPC1 | |
| SCHEMBL6799380 | 0.84 | ALDH1A1 (0.56) | MEP1BGAAALDH1A1KDM4ENPC1 | |
| SCHEMBL5090951 | 0.84 | CA1 (0.57) | GAAALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL7690859 | 0.84 | MEP1B (0.62) | MEP1BF2TMPRSS6KMT2APRSS1 | |
| SCHEMBL7675632 | 0.83 | SMN1; SMN2 (0.51) | MEP1BGAAALDH1A1KDM4ENPC1 | |
| SCHEMBL7663740 | 0.83 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2F2TMPRSS6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |