Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3325699 | 0.82 | ALDH1A1 (0.45) | PDE10AKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL718474 | 0.79 | HSP90AA1 (0.54) | KDM4EALDH1A1MAPTHSD17B10BLM | |
| SCHEMBL23204380 | 0.79 | DYRK1A (0.45) | PDE10AKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL23162725 | 0.79 | MAPT (0.42) | PDE10AKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL11836031 | 0.76 | ADORA2A (0.49) | PDE10AKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL5016163 | 0.74 | SMN1; SMN2 (0.54) | KDM4EALDH1A1MAPTHSD17B10MEN1 | |
| SCHEMBL2763257 | 0.74 | ALDH1A1 (0.44) | KDM4EALDH1A1MAPTHSD17B10MEN1 | |
| SCHEMBL5016286 | 0.73 | KDM4E (0.66) | KDM4EALDH1A1MAPTHSD17B10MEN1 | |
| SCHEMBL11828156 | 0.72 | LMNA (0.54) | PDE10AKDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL1489493 | 0.72 | POLB (0.56) | KDM4EALDH1A1MAPTHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135568-A1 | BENZOXAZEPINES AS INHIBITORS OF MTOR AND THEIR USE TO TREAT CANCER | EXELIXIS, INC. (US) | 2010-11-25 | — | — | WO | disclosed |