Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801437 | 0.89 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2KMT2AMAPTTP53 | |
| SCHEMBL3804902 | 0.85 | MAP2K1 (0.62) | MAP2K1ALDH1A1KMT2ACHEK1MAP2K2 | |
| SCHEMBL13063568 | 0.85 | MAP2K1 (0.46) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL3809196 | 0.84 | MAP2K1 (0.47) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL13063574 | 0.83 | MAP2K1 (0.52) | MAP2K1ALDH1A1SMN1; SMN2KMT2AMAPT | |
| SCHEMBL3800540 | 0.83 | MAP2K1 (0.45) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL13063812 | 0.83 | MAP2K1 (0.38) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL3804513 | 0.82 | MAP2K1 (0.44) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL13063589 | 0.81 | MAP2K1 (0.43) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 | |
| SCHEMBL3807711 | 0.81 | MAP2K1 (0.43) | MAP2K1CHEK1MAP2K2MAPK10PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |