Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 4/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3801316 | 0.89 | MAP2K1 (0.45) | ALDH1A1SMN1; SMN2KMT2AMAPTTP53 | |
| SCHEMBL13063861 | 0.85 | MAP2K1 (0.48) | ALDH1A1KMT2AMAPTMEN1POLB | |
| SCHEMBL13063853 | 0.85 | SRC (0.38) | ALDH1A1SMN1; SMN2KMT2AMAPTTP53 | |
| SCHEMBL3803390 | 0.84 | MAP2K1 (0.35) | ALDH1A1SMN1; SMN2KMT2AMAPTTP53 | |
| SCHEMBL13063827 | 0.83 | LMNA (0.39) | ALDH1A1TP53LMNA | |
| SCHEMBL13063540 | 0.82 | SRC (0.37) | KMT2AMAPTTP53LMNA | |
| SCHEMBL3804582 | 0.81 | MAP2K1 (0.42) | ALDH1A1SMN1; SMN2KMT2AMAPTTP53 | |
| SCHEMBL3804823 | 0.81 | ADRA2A (0.36) | BRAF | |
| SCHEMBL3809160 | 0.80 | LRRK2 (0.35) | LMNALRRK2 | |
| SCHEMBL13063542 | 0.79 | SRC (0.36) | MAPTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |
| WO-2010145197-A1 | NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMDIES AS MEK INHIBITORS | CHEMIZON (BEIJING), LTD. (CN) | 2010-12-23 | — | — | WO | disclosed |