Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 4/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1475644 | 0.89 | MAPKAPK5 (0.58) | MAPKAPK5EGFRSYKCFTRFGFR1 | |
| SCHEMBL3801487 | 0.88 | MAPKAPK5 (0.61) | MAPKAPK5 | |
| SCHEMBL3797323 | 0.87 | MAPKAPK5 (0.46) | MAPKAPK5EGFRSYKFGFR1KDR | |
| SCHEMBL3798405 | 0.84 | MAPKAPK5 (0.50) | MAPKAPK5JAK2 | |
| SCHEMBL3798752 | 0.81 | MAPKAPK5 (0.61) | MAPKAPK5SYKSRCKDR | |
| SCHEMBL1476031 | 0.81 | MAPKAPK5 (0.56) | MAPKAPK5EGFRSYKFGFR1BRAF | |
| SCHEMBL3805490 | 0.80 | MAPKAPK5 (0.53) | MAPKAPK5SYKPTK2 | |
| SCHEMBL3802993 | 0.80 | MAPKAPK5 (0.48) | MAPKAPK5SYKJAK2PTK2 | |
| SCHEMBL2220311 | 0.79 | MAPKAPK5 (0.74) | MAPKAPK5EGFRSYKSRCKDR | |
| SCHEMBL3801248 | 0.79 | MAPKAPK5 (0.47) | MAPKAPK5SYKFGFR1JAK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029602-B1 | TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-04-21 | — | — | EP | claimed |